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A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract

Yoon, Jonghee; Joseph, James; Waterhouse, Dale J.; Luthman, A. Siri; Gordon, George S. D.; di Pietro, Massimiliano; Januszewicz, Wladyslaw; Fitzgerald, Rebecca C.; Bohndiek, Sarah E.

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Authors

Jonghee Yoon

James Joseph

Dale J. Waterhouse

A. Siri Luthman

Massimiliano di Pietro

Wladyslaw Januszewicz

Rebecca C. Fitzgerald

Sarah E. Bohndiek



Abstract

Hyperspectral imaging (HSI) enables visualisation of morphological and biochemical information, which could improve disease diagnostic accuracy. Unfortunately, the wide range of image distortions that arise during flexible endoscopy in the clinic have made integration of HSI challenging. To address this challenge, we demonstrate a hyperspectral endoscope (HySE) that simultaneously records intrinsically co-registered hyperspectral and standard-of-care white light images, which allows image distortions to be compensated computationally and an accurate hyperspectral data cube to be reconstructed as the endoscope moves in the lumen. Evaluation of HySE performance shows excellent spatial, spectral and temporal resolution and high colour fidelity. Application of HySE enables: quantification of blood oxygenation levels in tissue mimicking phantoms; differentiation of spectral profiles from normal and pathological ex vivo human tissues; and recording of hyperspectral data under freehand motion within an intact ex vivo pig oesophagus model. HySE therefore shows potential for enabling HSI in clinical endoscopy.

Citation

Yoon, J., Joseph, J., Waterhouse, D. J., Luthman, A. S., Gordon, G. S. D., di Pietro, M., …Bohndiek, S. E. (2019). A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract. Nature Communications, 10, https://doi.org/10.1038/s41467-019-09484-4

Journal Article Type Article
Acceptance Date Mar 12, 2019
Online Publication Date Apr 23, 2019
Publication Date 2019-12
Deposit Date Jan 22, 2020
Publicly Available Date Mar 29, 2024
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 10
Article Number 1902
DOI https://doi.org/10.1038/s41467-019-09484-4
Public URL https://nottingham-repository.worktribe.com/output/2217141
Publisher URL https://www.nature.com/articles/s41467-019-09484-4#Abs1
Additional Information Received: 12 January 2018; Accepted: 12 March 2019; First Online: 23 April 2019; : The authors declare no competing interests.

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