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Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus

Taylor, Christopher H.; Young, Stuart; Fenn, Jonathan; Lamb, Angela L.; Lowe, Ann E.; Poulin, Benoit; MacColl, Andrew D. C.; Bradley, Janette E.


Stuart Young

Jonathan Fenn

Angela L. Lamb

Ann E. Lowe

Benoit Poulin

Professor of Evolutionary Ecology

Janette E. Bradley


1. The ability, propensity and need to mount an immune response vary both among individuals and within a single individual over time.

2. A wide array of parameters have been found to influence immune state in carefully controlled experiments, but we understand much less about which of these parameters are important in determining immune state in wild populations.

3. Diet can influence immune responses, for example when nutrient availability is limited. We therefore predict that natural dietary variation will play a role in modulating immune state, but this has never been tested.

4. We measured carbon and nitrogen stable isotope ratios in an island population of house mice Mus musculus domesticus as an indication of dietary variation, and the expression of a range of immune?related genes to represent immune state.

5. After accounting for potential confounding influences such as age, sex and helminth load, we found a significant association between carbon isotope ratio and levels of immune activity in the mesenteric lymph nodes, particularly in relation to the inflammatory response.

6. This association demonstrates the important interplay between diet and an animal's response to immune challenges, and therefore potentially its susceptibility to disease.


Taylor, C. H., Young, S., Fenn, J., Lamb, A. L., Lowe, A. E., Poulin, B., …Bradley, J. E. (2019). Immune state is associated with natural dietary variation in wild mice Mus musculus domesticus. Functional Ecology, 33(8), 1425-1435.

Journal Article Type Article
Acceptance Date Apr 10, 2019
Online Publication Date Apr 22, 2019
Publication Date 2019-08
Deposit Date May 2, 2019
Publicly Available Date Jun 10, 2019
Journal Functional Ecology
Print ISSN 0269-8463
Electronic ISSN 1365-2435
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 33
Issue 8
Pages 1425-1435
Keywords Ecology, Evolution, Behavior and Systematics
Public URL
Publisher URL


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