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Ultra-miniaturised spatial frequency domain imaging for improved early detection of gastrointestinal cancers

Crowley, Jane; Gordon, George

Authors

Jane Crowley



Abstract

The low five year-survival rates for gastrointestinal cancers evidences a strong clinical need to improve their early detection. Current imaging methods for early detection are expensive and rely on white light imaging which lacks sufficient contrast to spot a wide range of potential tumours. Changes in absorption and reduced scattering coefficients can be linked to pre-cancerous abnormalities, such as Barrett’s Oesophagus, and invasive squamous cell carcinoma, in the oesophagus. Spatial Frequency Domain Imaging (SFDI) is a low-cost imaging technique from which quantitative maps of absorption and reduced scattering coefficients may be obtained using structured illumination. We have developed a clinically translatable, ultra-miniaturised SFDI system using optical fibers (0.125 mm diameter) to project structured illumination and a miniature camera (< 1 mm diameter) to capture the pattern response for a sample under test. The total package could therefore be made < 1.1mm diameter, representing, to the best of our knowledge, the smallest full SFDI probe achieved to date. We have demonstrated recovery of absorption and reduced scattering maps with our system for tissue mimicking co-polymer in oil phantoms of biologically relevant absorption and scattering properties. This technology represents a first step towards a less-invasive, cost-effective device which produces close to real-time absorption and reduced scattering maps for improved in vivo disease detection of the gastrointestinal tract.

Citation

Crowley, J., & Gordon, G. (2023). Ultra-miniaturised spatial frequency domain imaging for improved early detection of gastrointestinal cancers. Proceedings of SPIE, 12393, Article 1239302. https://doi.org/10.1117/12.2648766

Journal Article Type Conference Paper
Conference Name Biomedical Applications of Light Scattering XIII
Conference Location San Francisco, United States
Acceptance Date Mar 16, 2023
Online Publication Date Mar 16, 2023
Publication Date Mar 16, 2023
Deposit Date Mar 31, 2023
Publicly Available Date May 24, 2023
Journal Proceedings of SPIE
Print ISSN 0277-786X
Electronic ISSN 1996-756X
Publisher SPIE
Peer Reviewed Peer Reviewed
Volume 12393
Article Number 1239302
ISBN 9781510658912
DOI https://doi.org/10.1117/12.2648766
Public URL https://nottingham-repository.worktribe.com/output/19009076
Publisher URL https://www.spiedigitallibrary.org/conference-proceedings-of-spie/12393/2648766/Ultra-miniaturised-spatial-frequency-domain-imaging-for-improved-early-detection/10.1117/12.2648766.short

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