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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Kunkle, Brian W.; Alzheimer Disease Genetics Consortium (ADGC),; Grenier-Boley, Benjamin; Sims, Rebecca; Bis, Joshua C.; Damotte, Vincent; Naj, Adam C.; Boland, Anne; Vronskaya, Maria; van der Lee, Sven J.; Amlie-Wolf, Alexandre; Bellenguez, C?line; Frizatti, Aura; Chouraki, Vincent; Martin, Eden R.; Sleegers, Kristel; Badarinarayan, Nandini; Jakobsdottir, Johanna; Hamilton-Nelson, Kara L.; Moreno-Grau, Sonia; Olaso, Robert; Raybould, Rachel; Chen, Yuning; Kuzma, Amanda B.; Hiltunen, Mikko; Morgan, Taniesha; Ahmad, Shahzad; Vardarajan, Badri N.; Epelbaum, Jacques; Hoffmann, Per; Boada, Merce; Beecham, Gary W.; Garnier, Jean-Guillaume; Harold, Denise; Fitzpatrick, Annette L.; Valladares, Otto; Moutet, Marie-Laure; Gerrish, Amy; Smith, Albert V.; Qu, Liming; Bacq, Delphine; Denning, Nicola; Jian, Xueqiu; Zhao, Yi; Del Zompo, Maria; Fox, Nick C.; Choi, Seung-Hoan; Mateo, Ignacio; Hughes, Joseph T.; Adams, Hieab H.; Malamon, John; Sanchez-Garcia, Florentino; Patel, Yogen; Brody, Jennifer A...

Authors

Brian W. Kunkle

Alzheimer Disease Genetics Consortium (ADGC),

Benjamin Grenier-Boley

Rebecca Sims

Joshua C. Bis

Vincent Damotte

Adam C. Naj

Anne Boland

Maria Vronskaya

Sven J. van der Lee

Alexandre Amlie-Wolf

C�line Bellenguez

Aura Frizatti

Vincent Chouraki

Eden R. Martin

Kristel Sleegers

Nandini Badarinarayan

Johanna Jakobsdottir

Kara L. Hamilton-Nelson

Sonia Moreno-Grau

Robert Olaso

Rachel Raybould

Yuning Chen

Amanda B. Kuzma

Mikko Hiltunen

Taniesha Morgan

Shahzad Ahmad

Badri N. Vardarajan

Jacques Epelbaum

Per Hoffmann

Merce Boada

Gary W. Beecham

Jean-Guillaume Garnier

Denise Harold

Annette L. Fitzpatrick

Otto Valladares

Marie-Laure Moutet

Amy Gerrish

Albert V. Smith

Liming Qu

Delphine Bacq

Nicola Denning

Xueqiu Jian

Yi Zhao

Maria Del Zompo

Nick C. Fox

Seung-Hoan Choi

Ignacio Mateo

Joseph T. Hughes

Hieab H. Adams

John Malamon

Florentino Sanchez-Garcia

Yogen Patel

Jennifer A. Brody

Beth A. Dombroski

Maria Candida Deniz Naranjo

Makrina Daniilidou

Gudny Eiriksdottir

Shubhabrata Mukherjee

David Wallon

James Uphill

Thor Aspelund

Laura B. Cantwell

Fabienne Garzia

Daniela Galimberti

Edith Hofer

Mariusz Butkiewicz

Bertrand Fin

Elio Scarpini

Chloe Sarnowski

Will S. Bush

St�phane Meslage

Johannes Kornhuber

Charles C. White

Yuenjoo Song

Robert C. Barber

Sebastiaan Engelborghs

Sabrina Sordon

Dina Voijnovic

Perrie M. Adams

Rik Vandenberghe

Manuel Mayhaus

L. Adrienne Cupples

Marilyn S. Albert

Peter P. De Deyn

Wei Gu

Jayanadra J. Himali

Duane Beekly

Alessio Squassina

Annette M. Hartmann

Adelina Orellana

Deborah Blacker

Eloy Rodriguez-Rodriguez

Simon Lovestone

Melissa E. Garcia

Rachelle S. Doody

Carmen Munoz-Fernadez

Rebecca Sussams

Honghuang Lin

Thomas J. Fairchild

Yolanda A. Benito

Clive Holmes

Hata Karamuji?-?omi?

Matthew P. Frosch

Hakan Thonberg

Wolfgang Maier

Gena Roschupkin

Bernardino Ghetti

Vilmantas Giedraitis

Amit Kawalia

Shuo Li

Ryan M. Huebinger

Lena Kilander

Susanne Moebus

Isabel Hern�ndez

M. Ilyas Kamboh

RoseMarie Brundin

James Turton

Qiong Yang

Mindy J. Katz

Letizia Concari

Jenny Lord

Alexa S. Beiser

C. Dirk Keene

Seppo Helisalmi

Iwona Kloszewska

Walter A. Kukull

Anne Maria Koivisto

Aoibhinn Lynch

Llu�s Tarraga

Eric B. Larson

Annakaisa Haapasalo

Brian Lawlor

Thomas H. Mosley

Richard B. Lipton

Vincenzo Solfrizzi

Michael Gill

W. T. Longstreth

Thomas J. Montine

Vincenza Frisardi

Monica Diez-Fairen

Fernando Rivadeneira

Ronald C. Petersen

Vincent Deramecourt

Ignacio Alvarez

Francesca Salani

Antonio Ciaramella

Eric Boerwinkle

Eric M. Reiman

Nathalie Fievet

Jerome I. Rotter

Joan S. Reisch

Olivier Hanon

Chiara Cupidi

A. G. Andre Uitterlinden

Donald R. Royall

Carole Dufouil

Raffaele Giovanni Maletta

Itziar de Rojas

Mary Sano

Alexis Brice

Roberta Cecchetti

Peter St George-Hyslop

Karen Ritchie

Magda Tsolaki

Debby W. Tsuang

Bruno Dubois

David Craig

Chuang-Kuo Wu

Hilkka Soininen

Despoina Avramidou

Roger L. Albin

Laura Fratiglioni

Antonia Germanou

Liana G. Apostolova

Lina Keller

Maria Koutroumani

Steven E. Arnold

Francesco Panza

Olymbia Gkatzima

Sanjay Asthana

Didier Hannequin

Patrice Whitehead

Craig S. Atwood

Paolo Caffarra

Harald Hampel

In�s Quintela

�ngel Carracedo

Lars Lannfelt

David C. Rubinsztein

Lisa L. Barnes

Florence Pasquier

Lutz Fr�lich

Sandra Barral

Bernadette McGuinness

Thomas G. Beach

Janet A. Johnston

James T. Becker

Peter Passmore

Eileen H. Bigio

Jonathan M. Schott

Thomas D. Bird

Jason D. Warren

Bradley F. Boeve

Michelle K. Lupton

James D. Bowen

Petra Proitsi

Adam Boxer

John F. Powell

James R. Burke

John S. K. Kauwe

Jeffrey M. Burns

Michelangelo Mancuso

Joseph D. Buxbaum

Ubaldo Bonuccelli

Nigel J. Cairns

Andrew McQuillin

Chuanhai Cao

Gill Livingston

Chris S. Carlson

Nicholas J. Bass

Cynthia M. Carlsson

John Hardy

Regina M. Carney

Jose Bras

Minerva M. Carrasquillo

Rita Guerreiro

Mariet Allen

Helena C. Chui

Elizabeth Fisher

Carlo Masullo

Elizabeth A. Crocco

Charles DeCarli

Gina Bisceglio

Malcolm Dick

Li Ma

Ranjan Duara

Neill R. Graff-Radford

Denis A. Evans

Angela Hodges

Kelley M. Faber

Martin Scherer

Kenneth B. Fallon

Matthias Riemenschneider

David W. Fardo

Reinhard Heun

Martin R. Farlow

Heike K�lsch

Steven Ferris

Markus Leber

Tatiana M. Foroud

Isabella Heuser

Douglas R. Galasko

Ina Giegling

Marla Gearing

Michael H�ll

Daniel H. Geschwind

John R. Gilbert

John Morris

Robert C. Green

Kevin Mayo

John H. Growdon

Thomas Feulner

Ronald L. Hamilton

Lindy E. Harrell

Dmitriy Drichel

Lawrence S. Honig

Thomas D. Cushion

Matthew J. Huentelman

Paul Hollingworth

Christine M. Hulette

Bradley T. Hyman

Rachel Marshall

Gail P. Jarvik

Alun Meggy

Erin Abner

Georgina E. Menzies

Lee-Way Jin

Ganna Leonenko

Luis M. Real

Gyungah R. Jun

Clinton T. Baldwin

Detelina Grozeva

Anna Karydas

Giancarlo Russo

Jeffrey A. Kaye

Ronald Kim

Frank Jessen

Neil W. Kowall

Bruno Vellas

Joel H. Kramer

Emma Vardy

Frank M. LaFerla

Karl-Heinz J�ckel

James J. Lah

Martin Dichgans

James B. Leverenz

David Mann

Allan I. Levey

Stuart Pickering-Brown

Andrew P. Lieberman

Norman Klopp

Kathryn L. Lunetta

H-Erich Wichmann

Constantine G. Lyketsos

Kevin Morgan

Daniel C. Marson

Frank Martiniuk

Christopher Medway

Deborah C. Mash

Markus M. N�then

Eliezer Masliah

Nigel M. Hooper

Wayne C. McCormick

Antonio Daniele

Susan M. McCurry

Anthony Bayer

Andrew N. McDavid

John Gallacher

Ann C. McKee

Hendrik van den Bussche

Marsel Mesulam

Carol Brayne

Bruce L. Miller

Steffi Riedel-Heller

Carol A. Miller

Joshua W. Miller

Ammar Al-Chalabi

John C. Morris

Christopher E. Shaw

Amanda J. Myers

Jens Wiltfang

Sid O�Bryant

John M. Olichney

Victoria Alvarez

Joseph E. Parisi

Andrew B. Singleton

Henry L. Paulson

John Collinge

William R. Perry

Simon Mead

Elaine Peskind

David H. Cribbs

Martin Rossor

Aimee Pierce

Natalie S. Ryan

Wayne W. Poon

Benedetta Nacmias

Huntington Potter

Sandro Sorbi

Joseph F. Quinn

Eleonora Sacchinelli

Ashok Raj

Gianfranco Spalletta

Murray Raskind

Carlo Caltagirone

Paola Boss�

Maria Donata Orfei

Barry Reisberg

Robert Clarke

Christiane Reitz

A David Smith

John M. Ringman

Donald Warden

Erik D. Roberson

Gordon Wilcock

Ekaterina Rogaeva

Amalia Cecilia Bruni

Howard J. Rosen

Maura Gallo

Roger N. Rosenberg

Yoav Ben-Shlomo

Mark A. Sager

Patrizia Mecocci

Andrew J. Saykin

Pau Pastor

Michael L. Cuccaro

Jeffery M. Vance

Julie A. Schneider

Lori S. Schneider

Susan Slifer

William W. Seeley

Amanda G. Smith

Joshua A. Sonnen

Salvatore Spina

Robert A. Stern

Russell H. Swerdlow

Mitchell Tang

Rudolph E. Tanzi

John Q. Trojanowski

Juan C. Troncoso

Vivianna M. Van Deerlin

Linda J. Van Eldik

Harry V. Vinters

Jean Paul Vonsattel

Sandra Weintraub

Kathleen A. Welsh-Bohmer

Kirk C. Wilhelmsen

Jennifer Williamson

Thomas S. Wingo

Randall L. Woltjer

Clinton B. Wright

Chang-En Yu

Lei Yu

Yasaman Saba

Alberto Pilotto

Maria J. Bullido

Oliver Peters

Paul K. Crane

David Bennett

Paola Bosco

Eliecer Coto

Virginia Boccardi

Phil L. De Jager

Alberto Lleo

Nick Warner

Oscar L. Lopez

Martin Ingelsson

Panagiotis Deloukas

Carlos Cruchaga

Caroline Graff

Rhian Gwilliam

Myriam Fornage

Alison M. Goate

Pascual Sanchez-Juan

Patrick G. Kehoe

Najaf Amin

Nilifur Ertekin-Taner

Claudine Berr

St�phanie Debette

Seth Love

Lenore J. Launer

Steven G. Younkin

Jean-Francois Dartigues

Chris Corcoran

M. Arfan Ikram

Dennis W. Dickson

Gael Nicolas

Dominique Campion

JoAnn Tschanz

Helena Schmidt

Hakon Hakonarson

Jordi Clarimon

Ron Munger

Reinhold Schmidt

Lindsay A. Farrer

Christine Van Broeckhoven

Michael C. O�Donovan

Anita L. DeStefano

Lesley Jones

Jonathan L. Haines

Jean-Francois Deleuze

Michael J. Owen

Vilmundur Gudnason

Richard Mayeux

Valentina Escott-Price

Bruce M. Psaty

Alfredo Ramirez

Li-San Wang

Agustin Ruiz

Cornelia M. van Duijn

Peter A. Holmans

Sudha Seshadri

Julie Williams

Phillippe Amouyel

Gerard D. Schellenberg

Jean-Charles Lambert

Margaret A. Pericak-Vance

The European Alzheimer�s Disease Initiative (EADI),

Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),

Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer�s Disease Consortium (GERAD/PERADES),



Citation

Kunkle, B. W., Alzheimer Disease Genetics Consortium (ADGC),, Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., …Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),. (2019). Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics, 51(3), 414-430. https://doi.org/10.1038/s41588-019-0358-2

Journal Article Type Article
Acceptance Date Jan 22, 2019
Online Publication Date Feb 28, 2019
Publication Date 2019-03
Deposit Date Jul 27, 2020
Journal Nature Genetics
Print ISSN 1061-4036
Electronic ISSN 1546-1718
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 51
Issue 3
Pages 414-430
DOI https://doi.org/10.1038/s41588-019-0358-2
Keywords Genetics
Public URL https://nottingham-repository.worktribe.com/output/1862753