Skip to main content

Research Repository

Advanced Search

PdII-Mediated Oxidative Amination for Access to a 9-Azabicyclo[4.2.1]nonane Compound Library and Anatoxin-a

Dawood, Rafid S.; Chidipudi, Suresh R.; O'Connor, Daniel C.; Lewis, William; Hamza, Daniel; Pearce, Christopher A.; Jones, Geraint; Wilkie, Ross P.; Georgiou, Irene; Storr, Thomas E.; Moore, Jonathan C.; Stockman, Robert A.

PdII-Mediated Oxidative Amination for Access to a 9-Azabicyclo[4.2.1]nonane Compound Library and Anatoxin-a Thumbnail


Authors

Rafid S. Dawood

Suresh R. Chidipudi

Daniel C. O'Connor

William Lewis

Daniel Hamza

Christopher A. Pearce

Geraint Jones

Ross P. Wilkie

Irene Georgiou

Thomas E. Storr

Jonathan C. Moore

Profile Image

ROBERT STOCKMAN robert.stockman@nottingham.ac.uk
Professor of Organic Chemistry



Abstract

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Intramolecular oxidative amination of readily accessible aminocyclooct-4-enes provides rapid and regioselective access to the 9-azabicyclo[4.2.1]nonane framework characteristic of the natural product anatoxin-a (1). This has enabled the synthesis of sp3-rich chemical scaffolds suitable for diversification. A library of 881 lead-like compounds is reported alongside a formal synthesis of anatoxin-a (1).

Citation

Dawood, R. S., Chidipudi, S. R., O'Connor, D. C., Lewis, W., Hamza, D., Pearce, C. A., …Stockman, R. A. (2018). PdII-Mediated Oxidative Amination for Access to a 9-Azabicyclo[4.2.1]nonane Compound Library and Anatoxin-a. European Journal of Organic Chemistry, 2018(40), 5558-5561. https://doi.org/10.1002/ejoc.201801209

Journal Article Type Article
Acceptance Date Oct 18, 2018
Online Publication Date Oct 18, 2018
Publication Date Nov 1, 2018
Deposit Date Sep 17, 2019
Publicly Available Date Mar 28, 2024
Journal European Journal of Organic Chemistry
Print ISSN 1434-193X
Electronic ISSN 1099-0690
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 2018
Issue 40
Pages 5558-5561
DOI https://doi.org/10.1002/ejoc.201801209
Public URL https://nottingham-repository.worktribe.com/output/1857623
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201801209
Additional Information This is the peer reviewed version of the following article: Dawood, R. S., Chidipudi, S. R., O'Connor, D. C., Lewis, W. , Hamza, D. , Pearce, C. A., Jones, G. , Wilkie, R. P., Georgiou, I. , Storr, T. E., Moore, J. C. and Stockman, R. A. (2018), PdII‐Mediated Oxidative Amination for Access to a 9‐Azabicyclo[4.2.1]nonane Compound Library and Anatoxin‐a. Eur. J. Org. Chem., 2018: 5558-5561, which has been published in final form at 10.1002/ejoc.201801209. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions

Files




You might also like



Downloadable Citations