Skip to main content

Research Repository

Advanced Search

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma

Howarth, Alison; Madureira, Patricia A.; Lockwood, George; Storer, Lisa C. D.; Grundy, Richard; Rahman, Ruman; Pilkington, Geoffrey J.; Hill, Richard

Authors

Alison Howarth

Patricia A. Madureira

George Lockwood

Lisa C. D. Storer

RICHARD GRUNDY richard.grundy@nottingham.ac.uk
Professor of Paediatric Neuro-Oncology

Geoffrey J. Pilkington

Richard Hill



Abstract

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which Accepted Article This article is protected by copyright. All rights reserved. are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.

Journal Article Type Article
Publication Date 2019-11
Journal Brain Pathology
Print ISSN 1015-6305
Electronic ISSN 1750-3639
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 29
Issue 6
Pages 707-725
APA6 Citation Howarth, A., Madureira, P. A., Lockwood, G., Storer, L. C. D., Grundy, R., Rahman, R., …Hill, R. (2019). Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma. Brain Pathology, 29(6), 707-725. https://doi.org/10.1111/bpa.12729
DOI https://doi.org/10.1111/bpa.12729
Keywords Pathology and Forensic Medicine; General Neuroscience; Clinical Neurology
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12729
Additional Information This is the peer reviewed version of the following article: Howarth, A. , Madureira, P. A., Lockwood, G. , Storer, L. C., Grundy, R. , Rahman, R. , Pilkington, G. J. and Hill, R. (2019), Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma. Brain Pathol, 29: 707-725. doi:10.1111/bpa.12729. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Files





Downloadable Citations

;