Alison Howarth
Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma
Howarth, Alison; Madureira, Patricia A.; Lockwood, George; Storer, Lisa C. D.; Grundy, Richard; Rahman, Ruman; Pilkington, Geoffrey J.; Hill, Richard
Authors
Patricia A. Madureira
George Lockwood
Lisa C. D. Storer
RICHARD GRUNDY richard.grundy@nottingham.ac.uk
Professor of Paediatric Neuro-Oncology
RUMAN RAHMAN RUMAN.RAHMAN@NOTTINGHAM.AC.UK
Professor of Molecular Neuro-Oncology
Geoffrey J. Pilkington
Richard Hill
Abstract
Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which Accepted Article This article is protected by copyright. All rights reserved. are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.
Citation
Howarth, A., Madureira, P. A., Lockwood, G., Storer, L. C. D., Grundy, R., Rahman, R., …Hill, R. (2019). Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma. Brain Pathology, 29(6), 707-725. https://doi.org/10.1111/bpa.12729
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 23, 2019 |
Online Publication Date | Apr 23, 2019 |
Publication Date | 2019-11 |
Deposit Date | Apr 30, 2019 |
Publicly Available Date | Apr 24, 2020 |
Journal | Brain Pathology |
Print ISSN | 1015-6305 |
Electronic ISSN | 1750-3639 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 29 |
Issue | 6 |
Pages | 707-725 |
DOI | https://doi.org/10.1111/bpa.12729 |
Keywords | Pathology and Forensic Medicine; General Neuroscience; Clinical Neurology |
Public URL | https://nottingham-repository.worktribe.com/output/1851241 |
Publisher URL | https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12729 |
Additional Information | This is the peer reviewed version of the following article: Howarth, A. , Madureira, P. A., Lockwood, G. , Storer, L. C., Grundy, R. , Rahman, R. , Pilkington, G. J. and Hill, R. (2019), Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma. Brain Pathol, 29: 707-725. doi:10.1111/bpa.12729. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Contract Date | Apr 30, 2019 |
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