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Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen—the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002–2006)

Wilde, Craig; Poostchi, Ali; Narendran, Rajesh; MacNab, Hamish K.; Hillman, Jonathan G.; Alexander, Phillip; Amoaku, Winfried M.; Vernon, Stephen A.

Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen—the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002–2006) Thumbnail


Authors

Craig Wilde

Ali Poostchi

Rajesh Narendran

Hamish K. MacNab

Jonathan G. Hillman

Phillip Alexander

WINFRIED AMOAKU winfried.amoaku@nottingham.ac.uk
Clinical Assoc Prof & Reader in Ophthalmology & Visual Sciences

Stephen A. Vernon



Abstract

Aims: To determine disc haemorrhages (DH) prevalence in an elderly UK population-the Bridlington Eye Assessment Project (BEAP).
Methods: Thirty-degree (30°) fundus photographs (3549 participants ≥65 years) were graded for DH/macula changes. Glaucoma evaluation included Goldmann tonometry, 26-point suprathreshold visual-fields and mydriatic slit-lamp assessment for glaucomatous optic neuropathy.
Results: 3548 participants with photographs in at least one eye. DH were present in 53 subjects (1.49%), increasing from 1.17% (65-69-year age-group) to 2.19% (80-84-year age53 group), p=0.06. DH was found in 9/96 (9.38%) right eyes (RE) with open angle glaucoma (OAG). Two of twelve RE (16.67%) with normal tension glaucoma (NTG) had DH. Prevalence in eyes without glaucoma was lower (32/3452, [0.93%]). Reticular pseudodrusen (RPD) occurred in 170/3212 (5.29%) subjects without DH, and 8/131 subjects (6.11%) with OAG. Twenty (20) eyes had normal tension glaucoma (NTG), 2 of whom had RPD (10%) (p=0.264). Within a logistic regression model, DH was associated with glaucoma (OR 10.2, 95% CI 5.32 - 19.72) and increasing age (OR 1.05, 95% CI 1.00-1.10, p=0.03). DH was associated with RPD (p=0.05) with univariate analysis but this was not statistically significant in the final adjusted model. There was no significant association with gender, diabetes mellitus (DM), hypertension treatment or AMD grade.
Conclusion: DH prevalence is 1.5% in those over 65 years old and significantly associated with glaucoma and increasing age. There appears to be increased RPD prevalence in eyes with DH and NTG with age acting as a confounding factor. Larger studies are required to fully assess the relationship and investigate a possible shared aetiology of choroidal ischaemia.

Journal Article Type Article
Acceptance Date Aug 27, 2018
Online Publication Date Nov 1, 2018
Publication Date 2019-04
Deposit Date Apr 16, 2019
Publicly Available Date May 2, 2019
Journal Eye
Print ISSN 0950-222X
Electronic ISSN 1476-5454
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 33
Issue 4
Pages 580-586
DOI https://doi.org/10.1038/s41433-018-0263-4
Public URL https://nottingham-repository.worktribe.com/output/1815704
Publisher URL https://www.nature.com/articles/s41433-018-0263-4

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