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Ring opening polymerisation of ɛ-caprolactone with novel microwave magnetic heating and cyto-compatible catalyst

Wang, Kaiyang; Ni, Ming; Dundas, Adam A.; Dimitrakis, Georgios; Irvine, Derek J.

Ring opening polymerisation of ɛ-caprolactone with novel microwave magnetic heating and cyto-compatible catalyst Thumbnail


Authors

Kaiyang Wang

Ming Ni

ADAM DUNDAS ADAM.DUNDAS1@NOTTINGHAM.AC.UK
Assistant Professor

DEREK IRVINE derek.irvine@nottingham.ac.uk
Professor of Materials Chemistry



Abstract

We report on the ring-opening polymerization of ɛ-caprolactone incorporated with a magnetic susceptible catalyst, FeCl3, via the use of microwave magnetic heating (HH) which primarily heats the bulk with a magnetic field (H-field) from an electromagnetic field (EMF). Such a process was compared to more commonly used heating methods, such as conventional heating (CH), i.e., oil bath, and microwave electric heating (EH), which is also referred to as microwave heating that primarily heats the bulk with an electric field (E-field). We identified that the catalyst is susceptible to both the E-field and H-field heating, and promoted the heating of the bulk. Which, we noticed such promotion was a lot more significant in the HH heating experiment. Further investigating the impact of such observed effects in the ROP of ɛ-caprolactone, we found that the HH experiments showed a more significant improvement in both the product Mwt and yield as the input power increased. However, when the catalyst concentration was reduced from 400:1 to 1600:1 (Monomer:Catalyst molar ratio), the observed differentiation in the Mwt and yield between the EH and the HH heating methods diminished, which we hypothesized to be due to the limited species available that were susceptible to microwave magnetic heating. But comparable product results between the HH and EH heating methods suggest that the HH heating method along with a magnetic susceptible catalyst could be an alternative solution to overcome the penetration depth problem associated with the EH heating methods. The cytotoxicity of the produced polymer was investigated to identify its potential application as biomaterials.

Journal Article Type Article
Acceptance Date Jan 19, 2023
Online Publication Date Feb 13, 2023
Publication Date Feb 13, 2023
Deposit Date Feb 18, 2023
Publicly Available Date Feb 20, 2023
Journal Frontiers in Bioengineering and Biotechnology
Electronic ISSN 2296-4185
Publisher Frontiers Media SA
Peer Reviewed Peer Reviewed
Volume 11
Article Number 1123477
DOI https://doi.org/10.3389/fbioe.2023.1123477
Keywords microwave synthesis, magnetic susceptible catalyst, biomaterial fabrication, PCL synthesis, controlled polymerization
Public URL https://nottingham-repository.worktribe.com/output/17443547
Publisher URL https://www.frontiersin.org/articles/10.3389/fbioe.2023.1123477/full
Additional Information Wang K, Ni M, Dundas AA, Dimitrakis G and Irvine DJ (2023) Ring opening polymerisation of ɛ-caprolactone with novel microwave magnetic heating and cyto-compatible catalyst. Front. Bioeng. Biotechnol. 11:1123477. doi: 10.3389/fbioe.2023.1123477

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