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Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents

Albaugh, Matthew D.; Hudziak, James J.; Spechler, Philip A.; Chaarani, Bader; Lepage, Claude; Jeon, Seun; Rioux, Pierre; Evans, Alan C.; Banaschewski, Tobias; Bokde, Arun; Desrivières, Sylvane; Flor, Herta; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean Luc; Martinot, Marie-Laure; Nees, Frauke; Orfanos, Dimitri; Poustka, Luise; Millenet, Sabina; Frohner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Potter, Alexandra S.; Garavan, Hugh; Consortium, IMAGEN

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Authors

Matthew D. Albaugh

James J. Hudziak

Philip A. Spechler

Bader Chaarani

Claude Lepage

Seun Jeon

Pierre Rioux

Alan C. Evans

Tobias Banaschewski

Arun Bokde

Sylvane Desrivières

Herta Flor

Andreas Heinz

Bernd Ittermann

Jean Luc Martinot

Marie-Laure Martinot

Frauke Nees

Dimitri Orfanos

Luise Poustka

Sabina Millenet

Juliane H. Frohner

Michael N. Smolka

Henrik Walter

Robert Whelan

Gunter Schumann

Alexandra S. Potter

Hugh Garavan

IMAGEN Consortium



Abstract

Few studies have examined the association between conduct problems and cerebral cortical development. Herein, we characterize the association between age-related brain change and conduct problems in a large longitudinal, community-based sample of adolescents. 1,039 participants from the IMAGEN study possessed psychopathology and surface-based morphometric data at study baseline (M = 14.42 years, SD = 0.40; 559 females) and 5-year follow-up. Self-reports of conduct problems were obtained using the Strengths and Difficulties Questionnaire (SDQ). Vertex-level linear mixed effects models were implemented using the Matlab toolbox, SurfStat. To investigate the extent to which cortical thickness maturation was qualified by dimensional measures of conduct problems, we tested for an interaction between age and SDQ Conduct Problems (CP) score. There was no main effect of CP score on cortical thickness; however, a significant “Age by CP” interaction was revealed in bilateral insulae, left inferior frontal gyrus, left rostral anterior cingulate, left posterior cingulate, and bilateral inferior parietal cortices. Across regions, follow-up analysis revealed higher levels of CP were associated with accelerated age-related thinning. Findings were not meaningfully altered when controlling for alcohol use, co-occurring psychopathology, and socioeconomic status. Results may help to further elucidate neurodevelopmental patterns linking adolescent conduct problems with adverse adult outcomes.

Citation

Albaugh, M. D., Hudziak, J. J., Spechler, P. A., Chaarani, B., Lepage, C., Jeon, S., …Consortium, I. (2023). Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents. Psychiatry Research: Neuroimaging, 330, Article 111614. https://doi.org/10.1016/j.pscychresns.2023.111614

Journal Article Type Article
Acceptance Date Feb 13, 2023
Online Publication Date Feb 15, 2023
Publication Date Apr 1, 2023
Deposit Date Feb 17, 2023
Publicly Available Date Mar 29, 2024
Journal Psychiatry Research: Neuroimaging
Print ISSN 0925-4927
Electronic ISSN 1872-7506
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 330
Article Number 111614
DOI https://doi.org/10.1016/j.pscychresns.2023.111614
Keywords Psychiatry and Mental health; Radiology, Nuclear Medicine and imaging; Neuroscience (miscellaneous)
Public URL https://nottingham-repository.worktribe.com/output/17384965
Publisher URL https://www.sciencedirect.com/science/article/pii/S0925492723000240
Additional Information This article is maintained by: Elsevier; Article Title: Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents; Journal Title: Psychiatry Research: Neuroimaging; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.pscychresns.2023.111614

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