Skip to main content

Research Repository

Advanced Search

High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer

Ibrahim, Asmaa; Miligy, Islam M.; Toss, Michael S.; Green, Andrew R.; Rakha, Emad A

High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer Thumbnail


Authors

Asmaa Ibrahim

Islam M. Miligy

Michael S. Toss

EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology



Abstract

Introduction: Inner centromere protein (INCENP) is a member of the chromosomal passenger complex (CPC) and plays a key role in mitosis and cell proliferation. This study aims to evaluate the clinical and prognostic significance of INCENP in invasive breast cancer (BC).

Methods: INCENP protein expression was evaluated on a tissue microarray of a large BC cohort (n=1295) using immunohistochemistry. At the mRNA level, INCENP expression was assessed using the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) (n=1980) and Cancer Genome Atlas (TCGA) BC cohorts (n=854). The correlations between INCENP expression, clinicopathological parameters and patient outcome were investigated.

Results: INCENP protein expression was detected in the nucleus and cytoplasm of the tumour cells. Its expression was significantly associated with features characteristic of aggressive BC behaviour including high tumour grade, larger tumour size and high Nottingham Prognostic Index scores. High INCENP nuclear expression was a predictor of shorter BC-specific survival (BCSS) in the whole cohort, as well as in the luminal subtype (p<0.001). High INCENP nuclear expression was predictive of poor prognosis in BC patients who received hormone treatment or chemotherapy.

Conclusion: High INCENP expression is a poor prognostic biomarker in BC with potential therapeutic benefits.

Citation

Ibrahim, A., Miligy, I. M., Toss, M. S., Green, A. R., & Rakha, E. A. (2023). High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer. Pathobiology, 90(6), 377–388. https://doi.org/10.1159/000529628

Journal Article Type Article
Acceptance Date Jan 31, 2023
Online Publication Date Apr 7, 2023
Publication Date 2023-12
Deposit Date Feb 2, 2023
Publicly Available Date Apr 7, 2023
Journal Pathobiology
Print ISSN 1015-2008
Electronic ISSN 1423-0291
Publisher Karger Publishers
Peer Reviewed Peer Reviewed
Volume 90
Issue 6
Pages 377–388
DOI https://doi.org/10.1159/000529628
Keywords Cell Biology, Molecular Biology, General Medicine, Pathology and Forensic Medicine
Public URL https://nottingham-repository.worktribe.com/output/16798591
Publisher URL https://www.karger.com/Article/Abstract/529628

Files







You might also like



Downloadable Citations