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Developing alkaline titanate surfaces for medical applications

Wadge, Matthew D.; McGuire, Jamie; Thomas, Kathryn G.; Stuart, Bryan W.; Felfel, Reda M.; Ahmed, Ifty; Grant, David M.

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Authors

Jamie McGuire

Kathryn G. Thomas

Bryan W. Stuart

Reda M. Felfel

DAVID GRANT DAVID.GRANT@NOTTINGHAM.AC.UK
Professor of Materials Science



Abstract

Improving the surface of medical implants by plasma spraying of a hydroxyapatite coating can be of critical importance to their longevity and the patient’s convalescence. However, residual stresses, cracking, undesired crystallisation and delamination of the coating compromise the implants lifetime. A promising alternative surface application is an alkali-chemical treatment to generate bioactive surfaces, such as sodium and calcium titanate and their derivatives. Such surfaces obviate the need for high temperatures and resulting micro-crack formation and potentially improve the bioactive and bone integration properties through their nanoporous structures. Also, metallic ions such as silver, gallium and copper can be substituted into the titanate structure with the potential to reduce or eliminate the infections. This review examines the formation and mechanisms of bioactive/antibacterial alkaline titanate surfaces, their successes and limitations, and explores the future development of implant interfaces via multifunctional titanate surfaces on Ti-based alloys and on alternative substrate materials.

Citation

Wadge, M. D., McGuire, J., Thomas, K. G., Stuart, B. W., Felfel, R. M., Ahmed, I., & Grant, D. M. (in press). Developing alkaline titanate surfaces for medical applications. International Materials Reviews, Article 2153217. https://doi.org/10.1080/09506608.2022.2153217

Journal Article Type Article
Acceptance Date Nov 22, 2022
Online Publication Date Jan 24, 2023
Deposit Date Mar 31, 2023
Publicly Available Date Mar 29, 2024
Journal International Materials Reviews
Print ISSN 0950-6608
Electronic ISSN 1743-2804
Publisher Informa UK Limited
Peer Reviewed Peer Reviewed
Article Number 2153217
DOI https://doi.org/10.1080/09506608.2022.2153217
Keywords Titanate; biomaterial; implant; surface; modification; substitution; antibacterial; bioactive; multifunctional
Public URL https://nottingham-repository.worktribe.com/output/16506690
Publisher URL https://www.tandfonline.com/doi/full/10.1080/09506608.2022.2153217
Additional Information © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.




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