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Peptide–Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes

Majkowska, Anna; Inostroza-Brito, Karla E.; Gonzalez, Mariel; Redondo-Gómez, Carlos; Rice, Alistair; Rodriguez-Cabello, Jose Carlos; Del Rio Hernandez, Armando E.; Mata, Alvaro


Anna Majkowska

Karla E. Inostroza-Brito

Mariel Gonzalez

Carlos Redondo-Gómez

Alistair Rice

Jose Carlos Rodriguez-Cabello

Armando E. Del Rio Hernandez


Multicomponent self-assembly offers opportunities for the design of complex and functional biomaterials with tunable properties. Here, we demonstrate how minor modifications in the molecular structures of peptide amphiphiles (PAs) and elastin-like recombinamers (ELs) can be used to generate coassembling tubular membranes with distinct structures, properties, and bioactivity. First, by introducing minor modifications in the charge density of PA molecules (PAK2, PAK3, PAK4), different diffusion-reaction processes can be triggered, resulting in distinct membrane microstructures. Second, by combining different types of these PAs prior to their coassembly with ELs, further modifications can be achieved, tuning the structures and properties of the tubular membranes. Finally, by introducing the cell adhesive peptide RGDS in either the PA or EL molecules, it is possible to harness the different diffusion-reaction processes to generate tubular membranes with distinct bioactivities. The study demonstrates the possibility to trigger and achieve minor but crucial differences in coassembling processes and tune material structure and bioactivity. The study demonstrates the possibility to use minor, yet crucial, differences in coassembling processes to tune material structure and bioactivity.


Majkowska, A., Inostroza-Brito, K. E., Gonzalez, M., Redondo-Gómez, C., Rice, A., Rodriguez-Cabello, J. C., …Mata, A. (2023). Peptide–Protein Coassemblies into Hierarchical and Bioactive Tubular Membranes. Biomacromolecules, 24(10), 4419-4429.

Journal Article Type Article
Acceptance Date Dec 15, 2022
Online Publication Date Jan 25, 2023
Publication Date Oct 9, 2023
Deposit Date Feb 18, 2023
Publicly Available Date Mar 3, 2023
Journal Biomacromolecules
Print ISSN 1525-7797
Electronic ISSN 1526-4602
Publisher American Chemical Society (ACS)
Peer Reviewed Peer Reviewed
Volume 24
Issue 10
Pages 4419-4429
Keywords Materials Chemistry; Polymers and Plastics; Biomaterials; Bioengineering
Public URL
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