Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide

Parilti, Rahmet; Caprasse, Jérémie; Riva, Raphaël; Alexandre, Michaël; Vandegaart, Hélène; Bebrone, Carine; Dupont-Gillain, Christine; Howdle, Steven M.; Jérôme, Christine

Abstract

© 2018 Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles with a well-defined spherical morphology and a diameter as low as 450 nm have been obtained in mild conditions. The encapsulation and release of the peptide were confirmed by antimicrobial tests that demonstrated for the first time a sustained release of the peptide from poly(2-hydroxyethyl methacrylate) microgels prepared by one-pot dispersion polymerization in supercritical carbon dioxide and then dispersed in water.

Citation

Parilti, R., Caprasse, J., Riva, R., Alexandre, M., Vandegaart, H., Bebrone, C., …Jérôme, C. (2018). Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide. Journal of Colloid and Interface Science, 532, 112-117. https://doi.org/10.1016/j.jcis.2018.07.125

• Journal Article Type: Article
• Acceptance Date: Jul 28, 2018
• Online Publication Date: Jul 29, 2018
• Publication Date: Dec 15, 2018
• Deposit Date: Mar 8, 2019
• Publicly Available Date: Jul 30, 2019
• Journal: Journal of Colloid and Interface Science
• Print ISSN: 0021-9797
• Electronic ISSN: 1095-7103
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 532
• Pages: 112-117
• DOI: https://doi.org/10.1016/j.jcis.2018.07.125
• Keywords: Colloid and Surface Chemistry; Electronic, Optical and Magnetic Materials; Surfaces, Coatings and Films; Biomaterials
• Public URL: https://nottingham-repository.worktribe.com/output/1619621
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0021979718308907?via%3Dihub