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Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy

Penon, Oriol; Mar�n, Mar�a J.; Amabilino, David B.; Russell, David A.; P�rez-Garc�a, Llu�sa

Authors

Oriol Penon

Mar�a J. Mar�n

David B. Amabilino

David A. Russell

Llu�sa P�rez-Garc�a



Abstract

© 2015 Elsevier Inc.. The preparation of novel porphyrin derivatives and their immobilization onto iron oxide nanoparticles to build up suitable nanotools for potential use in photodynamic therapy (PDT) has been explored. To achieve this purpose, a zinc porphyrin derivative, ZnPR-COOH, has been synthesized, characterized at the molecular level and immobilized onto previously synthesized iron oxide nanoparticles covered with oleylamine. The novel nanosystem (ZnPR-IONP) has been thoroughly characterized by a variety of techniques such as UV-Vis absorption spectroscopy, fluorescence spectroscopy, X-ray photoloectron spectroscopy (XPS) and transmission electron microscopy (TEM). In order to probe the capability of the photosensitizer for PDT, the singlet oxygen production of both ZnPR-IONP and the free ligand ZnPR-COOH have been quantified by measuring the decay in absorption of the anthracene derivative 9,10-anthracenedipropionic acid (ADPA), showing an important increase on singlet oxygen production when the porphyrin is incorporated onto the IONP (ZnPR-IONP).On the other hand, the porphyrin derivative PR-TRIS3OH, incorporating several polar groups (TRIS), was synthesized and immobilized with the intention of obtaining water soluble nanosystems (PR-TRIS-IONP). When the singlet oxygen production ability was evaluated, the values obtained were similar to ZnPR-COOH/. ZnPR-IONP, again much higher in the case of the nanoparticles PR-TRIS-IONP, with more than a twofold increase. The efficient singlet oxygen production of PR-TRIS-IONP together with their water solubility, points to the great promise that these new nanotools represent for PDT.

Journal Article Type Article
Acceptance Date Sep 24, 2015
Online Publication Date Sep 26, 2015
Publication Date Jan 15, 2016
Deposit Date Feb 25, 2019
Journal Journal of Colloid and Interface Science
Print ISSN 0021-9797
Electronic ISSN 1095-7103
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 462
Pages 154-165
DOI https://doi.org/10.1016/j.jcis.2015.09.060
Keywords Colloid and Surface Chemistry; Electronic, Optical and Magnetic Materials; Surfaces, Coatings and Films; Biomaterials
Public URL https://nottingham-repository.worktribe.com/output/1582833
Publisher URL https://www.sciencedirect.com/science/article/pii/S0021979715302307
Additional Information This article is maintained by: Elsevier; Article Title: Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy; Journal Title: Journal of Colloid and Interface Science; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jcis.2015.09.060; Content Type: article; Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.


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