Oriol Penon
Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy
Penon, Oriol; Mar�n, Mar�a J.; Amabilino, David B.; Russell, David A.; P�rez-Garc�a, Llu�sa
Authors
Mar�a J. Mar�n
David B. Amabilino
David A. Russell
Llu�sa P�rez-Garc�a
Abstract
© 2015 Elsevier Inc.. The preparation of novel porphyrin derivatives and their immobilization onto iron oxide nanoparticles to build up suitable nanotools for potential use in photodynamic therapy (PDT) has been explored. To achieve this purpose, a zinc porphyrin derivative, ZnPR-COOH, has been synthesized, characterized at the molecular level and immobilized onto previously synthesized iron oxide nanoparticles covered with oleylamine. The novel nanosystem (ZnPR-IONP) has been thoroughly characterized by a variety of techniques such as UV-Vis absorption spectroscopy, fluorescence spectroscopy, X-ray photoloectron spectroscopy (XPS) and transmission electron microscopy (TEM). In order to probe the capability of the photosensitizer for PDT, the singlet oxygen production of both ZnPR-IONP and the free ligand ZnPR-COOH have been quantified by measuring the decay in absorption of the anthracene derivative 9,10-anthracenedipropionic acid (ADPA), showing an important increase on singlet oxygen production when the porphyrin is incorporated onto the IONP (ZnPR-IONP).On the other hand, the porphyrin derivative PR-TRIS3OH, incorporating several polar groups (TRIS), was synthesized and immobilized with the intention of obtaining water soluble nanosystems (PR-TRIS-IONP). When the singlet oxygen production ability was evaluated, the values obtained were similar to ZnPR-COOH/. ZnPR-IONP, again much higher in the case of the nanoparticles PR-TRIS-IONP, with more than a twofold increase. The efficient singlet oxygen production of PR-TRIS-IONP together with their water solubility, points to the great promise that these new nanotools represent for PDT.
Citation
Penon, O., Marín, M. J., Amabilino, D. B., Russell, D. A., & Pérez-García, L. (2016). Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy. Journal of Colloid and Interface Science, 462, 154-165. https://doi.org/10.1016/j.jcis.2015.09.060
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 24, 2015 |
Online Publication Date | Sep 26, 2015 |
Publication Date | Jan 15, 2016 |
Deposit Date | Feb 25, 2019 |
Journal | Journal of Colloid and Interface Science |
Print ISSN | 0021-9797 |
Electronic ISSN | 1095-7103 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 462 |
Pages | 154-165 |
DOI | https://doi.org/10.1016/j.jcis.2015.09.060 |
Keywords | Colloid and Surface Chemistry; Electronic, Optical and Magnetic Materials; Surfaces, Coatings and Films; Biomaterials |
Public URL | https://nottingham-repository.worktribe.com/output/1582833 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0021979715302307 |
Additional Information | This article is maintained by: Elsevier; Article Title: Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy; Journal Title: Journal of Colloid and Interface Science; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jcis.2015.09.060; Content Type: article; Copyright: Copyright © 2015 Elsevier Inc. All rights reserved. |
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search