Evolution of treatment targets in Crohn’s disease

White, Jonathan R.; Jairath, Vipul; Moran, Gordon W.

Abstract

Crohn’s disease is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, associated with significantly morbidity due to both symptoms and complications that have a considerable detrimental impact on a patient’s quality of life. An early treat to target approach with disease modifying agents has been shown to significantly improve long term outcomes, demonstrated by a number of therapeutic targets in a number of modalities. This review will outline the current treatment targets and measures of disease burden in Crohn’s disease.

Citation

White, J. R., Jairath, V., & Moran, G. W. (2019). Evolution of treatment targets in Crohn’s disease. Best Practice and Research: Clinical Gastroenterology, 38-39, 1-9. https://doi.org/10.1016/j.bpg.2019.02.001

• Journal Article Type: Article
• Acceptance Date: Feb 14, 2019
• Online Publication Date: Feb 16, 2019
• Publication Date: 2019-02
• Deposit Date: Feb 20, 2019
• Publicly Available Date: Feb 17, 2020
• Journal: Best Practice & Research Clinical Gastroenterology
• Print ISSN: 1521-6918
• Electronic ISSN: 1532-1916
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 38-39
• Article Number: 101599
• Pages: 1-9
• DOI: https://doi.org/10.1016/j.bpg.2019.02.001
• Keywords: Crohn’s disease; Treatment targets; Patient reported outcomes; Clinician reported activity indices; Biomarkers; Endoscopy; Imaging; Histology
• Public URL: https://nottingham-repository.worktribe.com/output/1572006
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1521691819300022?via%3Dihub