Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities and Perspectives

Wang, Jin-Lei; Zhang, Nian-Zhang; Li, Ting-Ting; He, Jun-Jun; Elsheikha, Hany M; Zhu, Xing-Quan

Abstract

Important progress has been made in understanding how immunity is elicited against Toxoplasma gondii - a complex pathogen with multiple mechanisms of immune evasion. Many vaccine candidates have been tested using various strategies in animal models. However, none of these strategies has delivered as yet, and important challenges remain in the development of vaccines that can eliminate the tissue cysts and/or fully block vertical transmission. In this review, we provide an overview of the current understanding of the host immune response to T. gondii infection and summarize the key limitations for the development of an effective, safe and durable toxoplasmosis vaccine. We also discuss how the successes and failures in developing and testing vaccine candidates have provided a roadmap for future vaccine development.

Citation

Wang, J., Zhang, N., Li, T., He, J., Elsheikha, H. M., & Zhu, X. (2019). Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities and Perspectives. Trends in Parasitology, 35(3), 239-253. https://doi.org/10.1016/j.pt.2019.01.005

• Journal Article Type: Article
• Acceptance Date: Jan 16, 2019
• Online Publication Date: Jan 29, 2019
• Publication Date: 2019-03
• Deposit Date: Dec 7, 2022
• Publicly Available Date: Dec 8, 2022
• Print ISSN: 1471-4922
• Electronic ISSN: 1471-5007
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 3
• Pages: 239-253
• DOI: https://doi.org/10.1016/j.pt.2019.01.005
• Public URL: https://nottingham-repository.worktribe.com/output/1498574
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1471492219300170?via%3Dihub