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Brain simulation as a cloud service: The Virtual Brain on EBRAINS

Schirner, Michael; Domide, Lia; Perdikis, Dionysios; Triebkorn, Paul; Stefanovski, Leon; Pai, Roopa; Prodan, Paula; Valean, Bogdan; Palmer, Jessica; Langford, Chloê; Blickensdörfer, André; van der Vlag, Michiel; Diaz-Pier, Sandra; Peyser, Alexander; Klijn, Wouter; Pleiter, Dirk; Nahm, Anne; Schmid, Oliver; Woodman, Marmaduke; Zehl, Lyuba; Fousek, Jan; Petkoski, Spase; Kusch, Lionel; Hashemi, Meysam; Marinazzo, Daniele; Mangin, Jean François; Flöel, Agnes; Akintoye, Simisola; Stahl, Bernd Carsten; Cepic, Michael; Johnson, Emily; Deco, Gustavo; McIntosh, Anthony R.; Hilgetag, Claus C.; Morgan, Marc; Schuller, Bernd; Upton, Alex; McMurtrie, Colin; Dickscheid, Timo; Bjaalie, Jan G.; Amunts, Katrin; Mersmann, Jochen; Jirsa, Viktor; Ritter, Petra

Brain simulation as a cloud service: The Virtual Brain on EBRAINS Thumbnail


Michael Schirner

Lia Domide

Dionysios Perdikis

Paul Triebkorn

Leon Stefanovski

Roopa Pai

Paula Prodan

Bogdan Valean

Jessica Palmer

Chloê Langford

André Blickensdörfer

Michiel van der Vlag

Sandra Diaz-Pier

Alexander Peyser

Wouter Klijn

Dirk Pleiter

Anne Nahm

Oliver Schmid

Marmaduke Woodman

Lyuba Zehl

Jan Fousek

Spase Petkoski

Lionel Kusch

Meysam Hashemi

Daniele Marinazzo

Jean François Mangin

Agnes Flöel

Simisola Akintoye

Michael Cepic

Emily Johnson

Gustavo Deco

Anthony R. McIntosh

Claus C. Hilgetag

Marc Morgan

Bernd Schuller

Alex Upton

Colin McMurtrie

Timo Dickscheid

Jan G. Bjaalie

Katrin Amunts

Jochen Mersmann

Viktor Jirsa

Petra Ritter


The Virtual Brain (TVB) is now available as open-source services on the cloud research platform EBRAINS ( It offers software for constructing, simulating and analysing brain network models including the TVB simulator; magnetic resonance imaging (MRI) processing pipelines to extract structural and functional brain networks; combined simulation of large-scale brain networks with small-scale spiking networks; automatic conversion of user-specified model equations into fast simulation code; simulation-ready brain models of patients and healthy volunteers; Bayesian parameter optimization in epilepsy patient models; data and software for mouse brain simulation; and extensive educational material. TVB cloud services facilitate reproducible online collaboration and discovery of data assets, models, and software embedded in scalable and secure workflows, a precondition for research on large cohort data sets, better generalizability, and clinical translation.

Journal Article Type Article
Acceptance Date Feb 3, 2022
Online Publication Date Feb 4, 2022
Publication Date May 1, 2022
Deposit Date Dec 31, 2022
Publicly Available Date Jan 3, 2023
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 251
Article Number 118973
Keywords Cognitive Neuroscience; Neurology
Public URL
Publisher URL


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