Tumour treating fields in a combinational therapeutic approach

Branter, Joshua; Basu, Surajit; Smith, Stuart

Abstract

© Branter et al. The standard of care for patients with newly diagnosed Glioblastoma multiforme (GBM) has remained unchanged since 2005, with patients undergoing maximal surgical resection, followed by radiotherapy plus concomitant and maintenance Temozolomide. More recently, Tumour treating fields (TTFields) therapy has become FDA approved for adult recurrent and adult newly-diagnosed GBM following the EF-11 and EF-14 trials, respectively. TTFields is a non-invasive anticancer treatment which utilizes medium frequency alternating electric fields to target actively dividing cancerous cells. TTFields selectively targets cells within mitosis through interacting with key mitotic proteins to cause mitotic arrest and cell death. TTFields therapy presents itself as a candidate for the combinational therapy route due to the lack of overlapping toxicities associated with electric fields. Here we review current literature pertaining to TTFields in combination with alkylating agents, radiation, anti-angiogenics, mitotic inhibitors, immunotherapies, and also with novel agents. This review highlights the observed synergistic and additive effects of combining TTFields with various other therapies, as well highlighting the strategies relating to combinations with electric fields.

Citation

Branter, J., Basu, S., & Smith, S. (2018). Tumour treating fields in a combinational therapeutic approach. Oncotarget, 9(93), 36631-36644. https://doi.org/10.18632/oncotarget.26344

• Journal Article Type: Article
• Acceptance Date: Oct 24, 2018
• Online Publication Date: Nov 7, 2018
• Publication Date: Nov 27, 2018
• Deposit Date: Jan 8, 2019
• Publicly Available Date: Jan 8, 2019
• Journal: Oncotarget
• Electronic ISSN: 1949-2553
• Publisher: Impact Journals
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 93
• Pages: 36631-36644
• DOI: https://doi.org/10.18632/oncotarget.26344
• Keywords: Oncology
• Public URL: https://nottingham-repository.worktribe.com/output/1451279
• Publisher URL: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=26344&path[]=82054