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The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma

Barraclough, Allison; Bishton, Mark; Cheah, Chan Y.; Villa, Diego; Hawkes, Eliza A.


Allison Barraclough

Mark Bishton

Chan Y. Cheah

Diego Villa

Eliza A. Hawkes


Grade 3B follicular lymphoma (G3B FL) is rare, accounting for only 5–10% of FLs. Not only has it been routinely excluded from clinical trials, but data published on diagnosis, outcomes, choice of therapies and role of imaging are conflicting. With the advent of increasingly diverse treatment options for low-grade (G1–3A) FL, and the molecular subcategorisation of high-grade B-cell lymphomas, characterisation and treatment of G3B FL is ever more important as extrapolation of data becomes more difficult. New data have emerged exploring unique genetic characteristics, specific features on positron emission tomography imaging, choice of therapy, and outcomes of G3B FL in the current era. The present review will summarise and appraise these new data, and offer recommendations based on current evidence.


Barraclough, A., Bishton, M., Cheah, C. Y., Villa, D., & Hawkes, E. A. (2021). The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma. British Journal of Haematology, 195(1), 15-24.

Journal Article Type Review
Acceptance Date Mar 1, 2022
Online Publication Date Mar 11, 2021
Publication Date 2021-10
Deposit Date Dec 15, 2022
Journal British Journal of Haematology
Print ISSN 0007-1048
Electronic ISSN 1365-2141
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 195
Issue 1
Pages 15-24
Keywords Hematology
Public URL
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