The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma

Barraclough, Allison; Bishton, Mark; Cheah, Chan Y.; Villa, Diego; Hawkes, Eliza A.

Abstract

Grade 3B follicular lymphoma (G3B FL) is rare, accounting for only 5–10% of FLs. Not only has it been routinely excluded from clinical trials, but data published on diagnosis, outcomes, choice of therapies and role of imaging are conflicting. With the advent of increasingly diverse treatment options for low-grade (G1–3A) FL, and the molecular subcategorisation of high-grade B-cell lymphomas, characterisation and treatment of G3B FL is ever more important as extrapolation of data becomes more difficult. New data have emerged exploring unique genetic characteristics, specific features on positron emission tomography imaging, choice of therapy, and outcomes of G3B FL in the current era. The present review will summarise and appraise these new data, and offer recommendations based on current evidence.

Citation

Barraclough, A., Bishton, M., Cheah, C. Y., Villa, D., & Hawkes, E. A. (2021). The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma. British Journal of Haematology, 195(1), 15-24. https://doi.org/10.1111/bjh.17404

• Journal Article Type: Review
• Acceptance Date: Mar 1, 2022
• Online Publication Date: Mar 11, 2021
• Publication Date: 2021-10
• Deposit Date: Dec 15, 2022
• Journal: British Journal of Haematology
• Print ISSN: 0007-1048
• Electronic ISSN: 1365-2141
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 195
• Issue: 1
• Pages: 15-24
• DOI: https://doi.org/10.1111/bjh.17404
• Keywords: Hematology
• Public URL: https://nottingham-repository.worktribe.com/output/14322783
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/bjh.17404