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The safety and clinical effectiveness of rapid infusion with CT-P10 in patients with non-Hodgkin's lymphoma or chronic lymphocytic leukemia: A retrospective non-interventional post-authorization safety study in Europe

Bishton, Mark; Marshall, Scott; Harchowal, Jatinder; Salles, Gilles; Golfier, Camille; Tucci, Alessandra; Fernández, Alicia Rodriguez; Sanchez Blanco, Jose Javier; Bocchia, Monica; Kim, Soo Kyoung; Lee, Young Nam; Zinzani, Pier Luigi

Authors

Mark Bishton

Scott Marshall

Jatinder Harchowal

Gilles Salles

Camille Golfier

Alessandra Tucci

Alicia Rodriguez Fernández

Jose Javier Sanchez Blanco

Monica Bocchia

Soo Kyoung Kim

Young Nam Lee

Pier Luigi Zinzani



Abstract

Rapid infusion (RI) of the rituximab biosimilar CT-P10 is currently only an approved treatment regimen for the treatment of rheumatoid arthritis. Although both CT-P10 and reference rituximab are known to be frequently administered using a RI regimen (≤90 min) in clinical practice, published data on the safety of RI of CT-P10 in patients with NHL and CLL are limited. Hence, this study collected real-world safety and effectiveness data on RI-CT-P10 from the medical records of 196 patients with NHL or CLL in 10 European centers, 6 months after the date of the first RI (index date); the infusion-related reaction (IRR) rate was compared to previously published data. Ten percent (95% confidence interval 6%–15%; n = 20/196) of patients experienced an infusion-related reaction (IRR) on day 1–2 post-index, which was not significantly different (p = 0.45) to the IRR rate for rituximab described in a previous meta-analysis (8.8%). During the observation period, 2% of patients experienced grade 3–5 IRRs and 85% (n = 166) experienced an adverse event (non-IRR). The most common reason for discontinuation of first-line CT-P10 was planned treatment completion (81%; n = 158). Complete response and partial response to CT-P10 was observed in 74% (n = 142/192) and 22% (n = 42/192) of patients, respectively. The results of this real-world study demonstrate that the safety and effectiveness profile of RI-CT-P10 is similar to RI of reference rituximab and therefore support the current use of RI-CT-P10 in patients with NHL and CLL.

Citation

Bishton, M., Marshall, S., Harchowal, J., Salles, G., Golfier, C., Tucci, A., …Zinzani, P. L. (2022). The safety and clinical effectiveness of rapid infusion with CT-P10 in patients with non-Hodgkin's lymphoma or chronic lymphocytic leukemia: A retrospective non-interventional post-authorization safety study in Europe. Hematological Oncology, 40(3), 370-380. https://doi.org/10.1002/hon.2978

Journal Article Type Article
Acceptance Date Jan 21, 2022
Online Publication Date Feb 15, 2022
Publication Date Aug 1, 2022
Deposit Date Nov 24, 2022
Publicly Available Date Nov 24, 2022
Journal Hematological Oncology
Print ISSN 0278-0232
Electronic ISSN 1099-1069
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 40
Issue 3
Pages 370-380
DOI https://doi.org/10.1002/hon.2978
Public URL https://nottingham-repository.worktribe.com/output/14036214
Publisher URL https://onlinelibrary.wiley.com/doi/10.1002/hon.2978

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