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MicroRNA in prostate cancer: functional importance and potential as circulating biomarkers

Jackson, Benjamin L.; Grabowska, Anna; Ratan, Hari L.

Authors

Benjamin L. Jackson

Anna Grabowska

Hari L. Ratan



Abstract

Background
This non-systematic review article aims to summarise the progress made in understanding the functional consequences of microRNA (miRNA) dysregulation in prostate cancer development, and the identification of potential miRNA targets as serum biomarkers for diagnosis or disease stratification.

Results
A number of miRNAs have been shown to influence key cellular processes involved in prostate tumourigenesis, including apoptosis-avoidance, cell proliferation and migration and the androgen signalling pathway. An overlapping group of miRNAs have shown differential expression in the serum of patients with prostate cancer of varying stages compared with unaffected individuals. The majority of studies thus far however, involve small numbers of patients and have shown variable and occasionally conflicting results

Conclusion
MiRNAs show promise as potential circulating biomarkers in prostate cancer, but larger prospective studies are required to validate particular targets and better define their clinical utility.

Journal Article Type Article
Publication Date 2014-12
Journal BMC Cancer
Electronic ISSN 1471-2407
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 14
Issue 1
Article Number 930
Pages 1-10
APA6 Citation Jackson, B. L., Grabowska, A., & Ratan, H. L. (2014). MicroRNA in prostate cancer: functional importance and potential as circulating biomarkers. BMC Cancer, 14(1), 1-10. https://doi.org/10.1186/1471-2407-14-930
DOI https://doi.org/10.1186/1471-2407-14-930
Keywords Prostatic neoplasms; MicroRNAs; Biological markers
Publisher URL https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-930

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