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Recombinant viruses for cancer therapy

Chulpanova, Daria S.; Solovyeva, Valeriya V.; Kitaeva, Kristina V.; Dunham, Stephen P.; Khaiboullina, Svetlana F.; Rizvanov, Albert A.

Authors

Daria S. Chulpanova

Valeriya V. Solovyeva

Kristina V. Kitaeva

Svetlana F. Khaiboullina

Albert A. Rizvanov



Abstract

Recombinant viruses are novel therapeutic agents that can be utilized for treatment of various diseases, including cancers. Recombinant viruses can be engineered to express foreign transgenes and have a broad tropism allowing gene expression in a wide range of host cells. They can be selected or designed for specific therapeutic goals; for example, recombinant viruses could be used to stimulate host immune response against tumor-specific antigens and therefore overcome the ability of the tumor to evade the host’s immune surveillance. Alternatively, recombinant viruses could express immunomodulatory genes which stimulate an anti-cancer immune response. Oncolytic viruses can replicate specifically in tumor cells and induce toxic effects leading to cell lysis and apoptosis. However, each of these approaches face certain difficulties that must be resolved to achieve maximum therapeutic efficacy. In this review we discuss actively developing approaches for cancer therapy based on recombinant viruses, problems that need to be overcome, and possible prospects for further development of recombinant virus based therapy.

Journal Article Type Article
Publication Date Sep 25, 2018
Journal Biomedicines
Electronic ISSN 2227-9059
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 6
Issue 4
Article Number 94
Pages 1-14
APA6 Citation Chulpanova, D. S., Solovyeva, V. V., Kitaeva, K. V., Dunham, S. P., Khaiboullina, S. F., & Rizvanov, A. A. (2018). Recombinant viruses for cancer therapy. Biomedicines, 6(4), 1-14. https://doi.org/10.3390/biomedicines6040094
DOI https://doi.org/10.3390/biomedicines6040094
Keywords recombinant viruses; virus-based vaccines; oncolytic viruses; gene therapy; cell therapy; chimeric antigen receptor (CAR) T-cell therapy
Publisher URL https://www.mdpi.com/2227-9059/6/4/94

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