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Functional hierarchy of oculomotor and visual motion subnetworks within the human cortical optokinetic system

Ruehl, Ria Maxine; Hoffstaedter, Felix; Reid, Andrew; Eickhoff, Simon; zu Eulenburg, Peter

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Authors

Ria Maxine Ruehl

Felix Hoffstaedter

Andrew Reid

Simon Eickhoff

Peter zu Eulenburg



Abstract

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Optokinetic look nystagmus (look OKN) is known to engage cortical visual motion and oculomotor hubs. Their functional network hierarchy, however, and the role of the cingulate eye field (CEF) and the dorsolateral prefrontal cortex (DLPFC) in particular have not been investigated. We used look OKN in fMRI to identify all cortical visual motion and oculomotor hubs involved. Using these activations as seed regions, we employed hierarchical clustering in two differing resting state conditions from a separate public data set. Robust activations in the CEF highlight its functional role in OKN and involvement in higher order oculomotor control. Deactivation patterns indicate a decreased modulatory involvement of the DLPFC. The hierarchical clustering revealed a changeable organization of the eye fields, hMT, V3A, and V6 depending on the resting state condition, segregating executive from higher order visual subnetworks. Overall, hierarchical clustering seems to allow for a robust delineation of physiological cortical networks.

Citation

Ruehl, R. M., Hoffstaedter, F., Reid, A., Eickhoff, S., & zu Eulenburg, P. (2019). Functional hierarchy of oculomotor and visual motion subnetworks within the human cortical optokinetic system. Brain Structure and Function, 224, 567-582. https://doi.org/10.1007/s00429-018-1788-9

Journal Article Type Article
Acceptance Date Nov 2, 2018
Online Publication Date Nov 13, 2018
Publication Date Mar 4, 2019
Deposit Date Dec 4, 2018
Publicly Available Date Nov 14, 2019
Journal Brain Structure and Function
Print ISSN 1863-2653
Electronic ISSN 1863-2661
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 224
Pages 567-582
DOI https://doi.org/10.1007/s00429-018-1788-9
Keywords Anatomy; General Neuroscience; Histology
Public URL https://nottingham-repository.worktribe.com/output/1363879
Publisher URL https://link.springer.com/article/10.1007%2Fs00429-018-1788-9
Contract Date Dec 4, 2018

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