Non-invasive detection of animal nerve impulses with an atomic magnetometer operating near quantum limited sensitivity

Jensen, Kasper; Budvytyte, Rima; Thomas, Rodrigo A.; Wang, Tian; Fuchs, Annette M.; Balabas, Mikhail V.; Vasilakis, Georgios; Mosgaard, Lars D.; St�rkind, Hans C.; M�ller, J�rg H.; Heimburg, Thomas; Olesen, S�ren-Peter; Polzik, Eugene S.

Abstract

Magnetic fields generated by human and animal organs, such as the heart, brain and nervous system carry information useful for biological and medical purposes. These magnetic fields are most commonly detected using cryogenically-cooled superconducting magnetometers. Here we present the first detection of action potentials from an animal nerve using an optical atomic magnetometer. Using an optimal design we are able to achieve the sensitivity dominated by the quantum shot noise of light and quantum projection noise of atomic spins. Such sensitivity allows us to measure the nerve impulse with a miniature roomerature sensor which is a critical advantage for biomedical applications. Positioning the sensor at a distance of a few millimeters from the nerve, corresponding to the distance between the skin and nerves in biological studies, we detect the magnetic field generated by an action potential of a frog sciatic nerve. From the magnetic field measurements we determine the activity of the nerve and the temporal shape of the nerve impulse. This work opens new ways towards implementing optical magnetometers as practical devices for medical diagnostics.

Citation

Jensen, K., Budvytyte, R., Thomas, R. A., Wang, T., Fuchs, A. M., Balabas, M. V., …Polzik, E. S. (2016). Non-invasive detection of animal nerve impulses with an atomic magnetometer operating near quantum limited sensitivity. Scientific Reports, 6, Article 29638. https://doi.org/10.1038/srep29638

• Journal Article Type: Article
• Acceptance Date: Jun 22, 2016
• Online Publication Date: Jul 15, 2016
• Publication Date: Jul 15, 2016
• Deposit Date: Dec 6, 2018
• Publicly Available Date: Dec 21, 2018
• Journal: Scientific Reports
• Print ISSN: 2045-2322
• Electronic ISSN: 2045-2322
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Article Number: 29638
• DOI: https://doi.org/10.1038/srep29638
• Public URL: https://nottingham-repository.worktribe.com/output/1363758
• Publisher URL: https://www.nature.com/articles/srep29638#article-info