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Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: a systematic review

Yousefifard, Mahmoud; Sarveazad, Arash; Babahajian, Asrin; Baikpour, Masoud; Shokraneh, Farhad; Vaccaro, Alexander R.; Harrop, James S.; Fehlings, Michael G.; Hosseini, Mostafa; Rahimi-Movaghar, Vafa

Authors

Mahmoud Yousefifard

Arash Sarveazad

Asrin Babahajian

Masoud Baikpour

Farhad Shokraneh

Alexander R. Vaccaro

James S. Harrop

Michael G. Fehlings

Mostafa Hosseini

Vafa Rahimi-Movaghar



Abstract

It remains unclear whether biomarkers in the serum or cerebrospinal fluid (CSF) can be used for diagnosis or prognosis of spinal cord injuries (SCI). Therefore, a systematic review was undertaken to evaluate the prognostic or diagnostic value of serum and CSF biomarkers in assessing the severity of SCI and the outcome of patients. Two independent reviewers summarized the human studies retrieved from the electronic databases of Medline, Embase, Scopus and ISI Web of Science until April 2018. Seventeen studies were included (1065 patients aged 16 to 94 years old). Although the findings of the included studies suggest that inflammatory and structural proteins may be useful in assessing the severity of SCI and prediction of neurological outcome, the level of evidence is generally low. Given limitations to the available evidence, further investigation in this field is required using large prospective datasets with rigorous analysis of sensitivity, specificity and prediction.

Journal Article Type Article
Publication Date Nov 29, 2018
Journal Journal of Neurochemistry
Print ISSN 0022-3042
Publisher Wiley
Peer Reviewed Peer Reviewed
APA6 Citation Yousefifard, M., Sarveazad, A., Babahajian, A., Baikpour, M., Shokraneh, F., Vaccaro, A. R., …Rahimi-Movaghar, V. (2018). Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: a systematic review. Journal of Neurochemistry, https://doi.org/10.1111/jnc.14637
DOI https://doi.org/10.1111/jnc.14637
Keywords Biochemistry; Cellular and Molecular Neuroscience
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14637

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