Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: a systematic review

Yousefifard, Mahmoud; Sarveazad, Arash; Babahajian, Asrin; Baikpour, Masoud; Shokraneh, Farhad; Vaccaro, Alexander R.; Harrop, James S.; Fehlings, Michael G.; Hosseini, Mostafa; Rahimi-Movaghar, Vafa

doi:10.1111/jnc.14637

Authors

Mahmoud Yousefifard

Arash Sarveazad

Asrin Babahajian

Masoud Baikpour

Farhad Shokraneh

Alexander R. Vaccaro

James S. Harrop

Michael G. Fehlings

Mostafa Hosseini

Vafa Rahimi-Movaghar

Abstract

It remains unclear whether biomarkers in the serum or cerebrospinal fluid (CSF) can be used for diagnosis or prognosis of spinal cord injuries (SCI). Therefore, a systematic review was undertaken to evaluate the prognostic or diagnostic value of serum and CSF biomarkers in assessing the severity of SCI and the outcome of patients. Two independent reviewers summarized the human studies retrieved from the electronic databases of Medline, Embase, Scopus and ISI Web of Science until April 2018. Seventeen studies were included (1065 patients aged 16 to 94 years old). Although the findings of the included studies suggest that inflammatory and structural proteins may be useful in assessing the severity of SCI and prediction of neurological outcome, the level of evidence is generally low. Given limitations to the available evidence, further investigation in this field is required using large prospective datasets with rigorous analysis of sensitivity, specificity and prediction.

Citation

Yousefifard, M., Sarveazad, A., Babahajian, A., Baikpour, M., Shokraneh, F., Vaccaro, A. R., …Rahimi-Movaghar, V. (2018). Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: a systematic review. Journal of Neurochemistry, 149(3), 317-330. https://doi.org/10.1111/jnc.14637

Journal Article Type	Article
Acceptance Date	Nov 27, 2018
Online Publication Date	Nov 29, 2018
Publication Date	Nov 29, 2018
Deposit Date	Nov 30, 2018
Publicly Available Date	Nov 30, 2019
Journal	Journal of Neurochemistry
Print ISSN	0022-3042
Electronic ISSN	1471-4159
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	149
Issue	3
Pages	317-330
DOI	https://doi.org/10.1111/jnc.14637
Keywords	Biochemistry; Cellular and Molecular Neuroscience
Public URL	https://nottingham-repository.worktribe.com/output/1347377
Publisher URL	https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14637