Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: a systematic review

Yousefifard, Mahmoud; Sarveazad, Arash; Babahajian, Asrin; Baikpour, Masoud; Shokraneh, Farhad; Vaccaro, Alexander R.; Harrop, James S.; Fehlings, Michael G.; Hosseini, Mostafa; Rahimi-Movaghar, Vafa

Abstract

It remains unclear whether biomarkers in the serum or cerebrospinal fluid (CSF) can be used for diagnosis or prognosis of spinal cord injuries (SCI). Therefore, a systematic review was undertaken to evaluate the prognostic or diagnostic value of serum and CSF biomarkers in assessing the severity of SCI and the outcome of patients. Two independent reviewers summarized the human studies retrieved from the electronic databases of Medline, Embase, Scopus and ISI Web of Science until April 2018. Seventeen studies were included (1065 patients aged 16 to 94 years old). Although the findings of the included studies suggest that inflammatory and structural proteins may be useful in assessing the severity of SCI and prediction of neurological outcome, the level of evidence is generally low. Given limitations to the available evidence, further investigation in this field is required using large prospective datasets with rigorous analysis of sensitivity, specificity and prediction.

Citation

Yousefifard, M., Sarveazad, A., Babahajian, A., Baikpour, M., Shokraneh, F., Vaccaro, A. R., …Rahimi-Movaghar, V. (2018). Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: a systematic review. Journal of Neurochemistry, 149(3), 317-330. https://doi.org/10.1111/jnc.14637

• Journal Article Type: Article
• Acceptance Date: Nov 27, 2018
• Online Publication Date: Nov 29, 2018
• Publication Date: Nov 29, 2018
• Deposit Date: Nov 30, 2018
• Publicly Available Date: Nov 30, 2019
• Journal: Journal of Neurochemistry
• Print ISSN: 0022-3042
• Electronic ISSN: 1471-4159
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 149
• Issue: 3
• Pages: 317-330
• DOI: https://doi.org/10.1111/jnc.14637
• Keywords: Biochemistry; Cellular and Molecular Neuroscience
• Public URL: https://nottingham-repository.worktribe.com/output/1347377
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14637