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The complex roles of μ-opioid receptor phosphorylation: A key determinant in receptor signaling and regulation

Canals, Meritxell

Authors



Abstract

Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics. This Commentary focuses on two articles in the October 2015 issue of Molecular Pharmacology that investigate the role of μ-opioid receptor phosphorylation in receptor agonist binding and desensitization. The work of Birdsong et al. and Yousuf et al. clearly highlights the complexity that researchers face when trying to assess the signaling and regulatory consequences of G protein-coupled receptor phosphorylation.

Journal Article Type Review
Publication Date Jul 7, 2015
Journal Molecular Pharmacology
Print ISSN 0026-895X
Electronic ISSN 1521-0111
Publisher American Society for Pharmacology and Experimental Therapeutics
Peer Reviewed Peer Reviewed
Volume 88
Issue 4
Pages 814-815
APA6 Citation Canals, M. (2015). The complex roles of μ-opioid receptor phosphorylation: A key determinant in receptor signaling and regulation. Molecular Pharmacology, 88(4), 814-815. https://doi.org/10.1124/mol.115.100180
DOI https://doi.org/10.1124/mol.115.100180
Keywords G protein coupled receptor; metenkephalin; morphine; mu opiate receptor; enkephalin[2 dextro alanine 4 methylphenylalanine 5 glycine]; mu opiate receptor; protein binding; binding affinity; carboxy terminal sequence; human; ligand binding; priority journa
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