Orientation tuning and contrast dependence of continuous flash suppression in amblyopia and normal vision

Gao, Tina Y.; Ledgeway, Timothy; Lie, Alyssa L.; Anstice, Nicola; Black, Joanna; McGraw, Paul V.; Thompson, Benjamin

Abstract

Purpose: Suppression in amblyopia may be an unequal form of normal interocular suppression or a distinct pathophysiology. To explore this issue, we examined the orientation tuning and contrast dependence of continuous flash suppression (CFS) in adults with amblyopia and visually normal controls.

Methods: Nine patients (mean age, 26.9 ± SD 4.7 years) and 11 controls (mean age, 24.8 ± SD 5.3 years) participated. In the CFS paradigm, spatially one-dimensional noise refreshing at 10 Hz was displayed in one eye to induce suppression of the other eye, and suppression strength was measured by using a grating contrast increment detection task. In experiment 1, noise contrast was fixed and the orientation difference between the noise and the grating was varied. In experiment 2, noise and grating orientations were identical and noise contrast was varied.

Results: Suppression patterns varied in both groups. In experiment 1, controls showed consistently orientation-tuned CFS (mean half-height bandwidth, 35.8° ± SD 21.5°) with near-equal strength between eyes. Five of nine patients with amblyopia exhibited orientation-independent CFS. Eight patients had markedly unequal suppression between eyes. Experiment 2 found that increasing the noise contrast to the amblyopic eye may produce suppression of the fellow eye, but suppression remained unequal between eyes.

Conclusions: Our data revealed that orientation specificity in CFS was very broad or absent in some patients with amblyopia, which could not be predicted by clinical measures. Suppression was unbalanced across the entire contrast range for most patients. This suggests that abnormal early visual experience disrupts the development of interocular suppression mechanisms.

Citation

Gao, T. Y., Ledgeway, T., Lie, A. L., Anstice, N., Black, J., McGraw, P. V., & Thompson, B. (2018). Orientation tuning and contrast dependence of continuous flash suppression in amblyopia and normal vision. Investigative Ophthalmology & Visual Science, 59(13), 5462-5472. https://doi.org/10.1167/iovs.18-23954

• Journal Article Type: Article
• Acceptance Date: Oct 13, 2018
• Online Publication Date: Nov 19, 2018
• Publication Date: Nov 19, 2018
• Deposit Date: Nov 21, 2018
• Publicly Available Date: Nov 21, 2018
• Journal: Investigative Opthalmology & Visual Science
• Print ISSN: 0146-0404
• Electronic ISSN: 1552-5783
• Publisher: Association for Research in Vision and Ophthalmology
• Peer Reviewed: Peer Reviewed
• Volume: 59
• Issue: 13
• Pages: 5462-5472
• DOI: https://doi.org/10.1167/iovs.18-23954
• Public URL: https://nottingham-repository.worktribe.com/output/1293312
• Publisher URL: https://iovs.arvojournals.org/article.aspx?articleid=2715825#203726475