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Molecular mechanisms governing the stem cell's fate in brain cancer: factors of stemness and quiescence

Gulaia, Valeriia; Vadim, Kumeyko; Nikita, Shved; Eduardas, Cicinskas; Rybtsov, Stanislav; Ruzov, Alexey; Kagansky, Alexander

Authors

Valeriia Gulaia

Kumeyko Vadim

Shved Nikita

Cicinskas Eduardas

Stanislav Rybtsov

Alexey Ruzov

Alexander Kagansky



Abstract

Cellular quiescence is a reversible, non-cycling state controlled by epigenetic, transcriptional and niche-associated molecular factors. Quiescence is a condition where molecular signaling pathways maintain the poised cell-cycle state whilst enabling rapid cell cycle re-entry. To achieve therapeutic breakthroughs in oncology it is crucial to decipher these molecular mechanisms employed by the cancerous milieu to control, maintain and gear stem cells towards re-activation. Cancer stem-like cells (CSCs) have been extensively studied in most malignancies, including glioma. Here, the aberrant niche activities skew the quiescence/activation equilibrium, leading to rapid tumor relapse after surgery and/or chemotherapy. Unraveling quiescence mechanisms promises to afford prevention of (often multiple) relapses, a key problem in current glioma treatment. This review article covers the current knowledge regarding normal and aberrant cellular quiescence control whilst also exploring how different molecular mechanisms and properties of the neighboring cells can influence the molecular processes behind glioma stem cell quiescence.
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Journal Article Type Article
Publication Date Nov 19, 2018
Journal Frontiers in Cellular Neuroscience
Electronic ISSN 1662-5102
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 12
Article Number 388
APA6 Citation Gulaia, V., Vadim, K., Nikita, S., Eduardas, C., Rybtsov, S., Ruzov, A., & Kagansky, A. (2018). Molecular mechanisms governing the stem cell's fate in brain cancer: factors of stemness and quiescence. Frontiers in Cellular Neuroscience, 12, doi:10.3389/fncel.2018.00388
DOI https://doi.org/10.3389/fncel.2018.00388
Keywords Cellular quiescence; Neural stem cell; Cancer stem cell; Niche; Glioma
Publisher URL https://www.frontiersin.org/articles/10.3389/fncel.2018.00388/full

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