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Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ

Toss, Michael S.; Miligy, Islam M.; Gorringe, Kylie L.; McCaffrey, L.; Alkawaz, Abdulbaqi; Abidi, Asima; Ellis, Ian O.; Green, Andrew R.; Rakha, Emad A.


Michael S. Toss

Islam M. Miligy

Kylie L. Gorringe

L. McCaffrey

Abdulbaqi Alkawaz

Asima Abidi

Professor of Breast Cancer Pathology


Legumain is a proteolytic enzyme and playing a role in the regulation of cell proliferation in invasive breast cancer. Studies evaluating its role in ductal carcinoma in situ (DCIS) are lacking. Here, we aimed to characterise legumain protein expression in DCIS and evaluate its prognostic significance. Legumain was assessed immunohistochemically in a tissue microarray of a well characterised cohort of DCIS (n=776 pure DCIS and n=239 DCIS associated with invasive breast cancer (DCIS-mixed)). Legumain immunoreactivity was scored in tumor cells and surrounding stroma and related to clinicopathological parameters and patient outcome. High legumain expression was observed in 23% of pure DCIS and was associated with features of high risk DCIS including higher nuclear grade, comedo necrosis, hormone receptor negativity, HER2 positivity and higher proliferation index. Legumain expression was higher in DCIS associated with invasive breast cancer than in pure DCIS (p

Journal Article Type Article
Publication Date Nov 14, 2018
Journal Modern Pathology
Print ISSN 0893-3952
Electronic ISSN 1530-0285
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 32
Pages 639–649
APA6 Citation Toss, M. S., Miligy, I. M., Gorringe, K. L., McCaffrey, L., Alkawaz, A., Abidi, A., …Rakha, E. A. (2018). Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ. Modern Pathology, 32, 639–649. doi:10.1038/s41379-018-0180-x
Keywords DCIS; Legumain; Poor prognosis; Invasive recurrence
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Legumain (LGMN) Is An Independent Predictor For Invasive Recurrence In Breast Ductal Carcinoma In Situ (DCIS) 30-10-2018 (1.6 Mb)

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