Mild cognitive impairment and mood: a systematic review

Yates, Jennifer A.; Clare, Linda; Woods, Robert T.

Abstract

This systematic review, with meta-analyses conducted where data were available, aimed to investigate the prevalence of symptoms of depression and anxiety in mild cognitive impairment (MCI), and to establish how symptoms of depression and anxiety relate to the progression from no cognitive impairment to MCI, and from MCI to dementia. Sixty studies were included in the review. Meta-analyses indicated that symptoms of depression and anxiety were more prevalent in people with MCI than in people with normal cognitive function, and increased the risk of progression from no cognitive impairment to MCI. There were mixed results regarding the effect of such symptoms on progression from MCI to dementia. The findings highlight the need for more research in this area, which can inform attempts to slow or halt the progression of cognitive impairment in later life, with resulting benefits for quality of life.

Citation

Yates, J. A., Clare, L., & Woods, R. T. (2013). Mild cognitive impairment and mood: a systematic review. Reviews in Clinical Gerontology, 23(04), 317-356. doi:10.1017/s0959259813000129

• Journal Article Type: Article
• Acceptance Date: Oct 1, 2013
• Online Publication Date: Nov 6, 2013
• Publication Date: Nov 30, 2013
• Deposit Date: Oct 24, 2018
• Journal: Reviews in Clinical Gerontology
• Print ISSN: 0959-2598
• Electronic ISSN: 1469-9036
• Publisher: Cambridge University Press (CUP)
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 04
• Pages: 317-356
• DOI: https://doi.org/10.1017/s0959259813000129
• Public URL: https://nottingham-repository.worktribe.com/output/1187946
• Publisher URL: https://www.cambridge.org/core/journals/reviews-in-clinical-gerontology/article/mild-cognitive-impairment-and-mood-a-systematic-review/732E8702B6DF6C5780F641819319B3CD