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If It Is Hard, It Is Worth Doing: Engineering Radical Enzymes from Anaerobes

Jäger, Christof M.; Croft, Anna K.


Christof M. Jäger


With a pressing need for sustainable chemistries, radical enzymes from anaerobes offer a shortcut for many chemical transformations and deliver highly sought-after functionalizations such as late-stage C-H functionalization, C-C bond formation, and carbon-skeleton rearrangements, among others. The challenges in handling these oxygen-sensitive enzymes are reflected in their limited industrial exploitation, despite what they may deliver. With an influx of structures and mechanistic understanding, the scope for designed radical enzymes to deliver wanted processes becomes ever closer. Combined with new advances in computational methods and workflows for these complex systems, the outlook for an increased use of radical enzymes in future processes is exciting.


Jäger, C. M., & Croft, A. K. (2023). If It Is Hard, It Is Worth Doing: Engineering Radical Enzymes from Anaerobes. Biochemistry, 62(2), 241-252.

Journal Article Type Article
Acceptance Date Sep 8, 2022
Online Publication Date Sep 19, 2022
Publication Date Jan 17, 2023
Deposit Date Sep 20, 2022
Publicly Available Date Sep 21, 2022
Journal Biochemistry
Electronic ISSN 1520-4995
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 62
Issue 2
Pages 241-252
Keywords Biochemistry
Public URL
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