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Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor?

Hurley, Matthew N.; Smyth, Alan R.

Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor? Thumbnail


Authors

Matthew N. Hurley

Alan R. Smyth



Abstract

Purpose of review: describe why this review is timely and relevant. The cystic fibrosis lung has long been appreciated as a competitive niche for complex interactions between bacterial species. The individual relationships between effects on the host, and thereafter clinical outcomes, has been poorly understood. We aim to describe the role of Staphyloccus aureus, one of the most commonly encountered bacteria cultured from the respiratory tracts of people with CF, and it’s complex interplay with other organisms, with particular attention to Pseudomonas aeruginosa.

Recent findings: describe the main themes in the literature covered by the article. We describe the challenges posed in understanding the role that S. aureus plays in the CF lung, including the difficulties in interpreting culture results depending upon sampling technique, relationships with P. aeruginosa and the rest of the microbiome, as well as discussing the relative merits and potential harms of antibiotic prophylaxis. Finally, we describe the particular challenge of methicillin-resistant S. aureus.

Summary: describe the implications of the findings for clinical practice or research. We describe research underway that will address the long-held contentious issues of antibiotic prophylaxis. We also describe the emerging research interest in determining whether, at differences phases in the evolution of CF airways infection, S. aureus infection can have both harmful and protective effects for the host.

Citation

Hurley, M. N., & Smyth, A. R. (2018). Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor?. Current Opinion in Pulmonary Medicine, 24(6), 586-591. https://doi.org/10.1097/MCP.0000000000000518

Journal Article Type Article
Acceptance Date Jul 26, 2018
Online Publication Date Aug 14, 2018
Publication Date Nov 1, 2018
Deposit Date Sep 7, 2018
Publicly Available Date Mar 28, 2024
Journal Current Opinion in Pulmonary Medicine
Print ISSN 1070-5287
Electronic ISSN 1531-6971
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 24
Issue 6
Pages 586-591
DOI https://doi.org/10.1097/MCP.0000000000000518
Keywords Staphylococcus aureus and MRSA; Interbacterial relationships; Respiratory sampling; Antibiotic prophylaxis
Public URL https://nottingham-repository.worktribe.com/output/1064352
Publisher URL https://journals.lww.com/co-pulmonarymedicine/Abstract/2018/11000/Staphylococcus_aureus_in_cystic_fibrosis___pivotal.10.aspx
Additional Information This is not the final published version of the article.