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Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non?diabetic dyspeptic patients

Hay, Peter D.; Corsetti, Maura; Tucker, Emily; Fox, Mark R.; Perkins, Alan


Peter D. Hay

Emily Tucker

Mark R. Fox

Alan Perkins


Background: Scintigraphy is used for overall assessment of gastric emptying. Adherence to an international consensus protocol is recommended to ensure quality; however, this has not been widely adopted because preparation of the “egg-beater” meal is inconvenient in clinical practice. In this report, we audit the tolerability and the results of gastric emptying scintigraphy with the 400 ml Tc-99 m-labeled liquid nutrient Nottingham Test Meal (NTM). Methods: Results from 330 consecutive adult, non-diabetic patients with dyspeptic symptoms referred for gastric scintigraphy were analyzed. Gastric half-emptying time (T50) and validated measurements of early- and late-phase gastric emptying were acquired. Postprandial sensations of fullness, bloating, heartburn, nausea, and epigastric pain were recorded using 100 mm visual analog scales (VAS) before and 0, 30, and 90 min after NTM ingestion. Results were compared with those previously obtained in healthy subjects. Key Results: Almost all (98%) of the patients were able to consume the 400 ml NTM. Considering early- and late-phase gastric emptying, frequently observed patterns included normal early- with slow late-phase (25%) and fast early- with slow late-phase emptying (27%). Abnormal score of fullness and/ or dyspeptic symptoms were observed in 88% of dyspeptic patients. Abnormal fullness at T0 (after completed drink ingestion) was associated with slow late phase of gastric emptying, especially in women. Conclusions: Gastric scintigraphy with the NTM is simple to perform and well tolerated. Whether the identified abnormal gastric emptying patterns could predict different treatment outcome in patients with functional dyspepsia is the subject of ongoing prospective studies.


Hay, P. D., Corsetti, M., Tucker, E., Fox, M. R., & Perkins, A. (2022). Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non?diabetic dyspeptic patients. Neurogastroenterology and Motility,

Journal Article Type Article
Acceptance Date Aug 5, 2022
Online Publication Date Sep 8, 2022
Publication Date Sep 8, 2022
Deposit Date Aug 23, 2022
Publicly Available Date Sep 9, 2023
Journal Neurogastroenterology & Motility
Print ISSN 1350-1925
Electronic ISSN 1365-2982
Publisher Wiley
Peer Reviewed Peer Reviewed
Keywords Gastroenterology; Endocrine and Autonomic Systems; Physiology
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