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Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia

Hentchke, Marta Ribiero; da Cunha Filho, Edson Vieira; Vieira, Matias Costa; Paula, Letícia Germany; Mistry, Hiten D.; Pinheiro da Costa, Bartira Ercília; Poli-de-Figueiredo, Carlos Eduardo


Marta Ribiero Hentchke

Edson Vieira da Cunha Filho

Matias Costa Vieira

Letícia Germany Paula

Hiten D. Mistry

Bartira Ercília Pinheiro da Costa

Carlos Eduardo Poli-de-Figueiredo


Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE).
Methods: Case-control study conducted at São Lucas Hospital. Endocan-1 and PlGF levels were quantified in maternal plasma using MagPlexTH-C microspheres system and analysed by ANCOVA adjusted by BMI, gestational age and maternal age. To estimate the difference between groups, mean ratio (MR) and 95% confidence interval (CI) were calculated. Pearson correlation test was used to establish any association between Endocan-1 and PlGF levels. The null hypothesis was rejected when p


Hentchke, M. R., da Cunha Filho, E. V., Vieira, M. C., Paula, L. G., Mistry, H. D., Pinheiro da Costa, B. E., & Poli-de-Figueiredo, C. E. (2018). Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia. Revista Brasileira de Ginecologia e Obstetrícia, 40(10), 593-598.

Journal Article Type Article
Acceptance Date Jul 2, 2018
Online Publication Date Oct 23, 2018
Publication Date Oct 31, 2018
Deposit Date Aug 15, 2018
Publicly Available Date Oct 29, 2018
Print ISSN 0100-7203
Electronic ISSN 1806-9339
Publisher Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Peer Reviewed Peer Reviewed
Volume 40
Issue 10
Pages 593-598
Keywords Pregnancy-induced hypertension; Preeclampsia; Endothelial function; Biomarkers; Preeclampsia, cytokines
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