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Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia

Hentchke, Marta Ribiero; da Cunha Filho, Edson Vieira; Vieira, Matias Costa; Paula, Letícia Germany; Mistry, Hiten D.; Pinheiro da Costa, Bartira Ercília; Poli-de-Figueiredo, Carlos Eduardo


Marta Ribiero Hentchke

Edson Vieira da Cunha Filho

Matias Costa Vieira

Letícia Germany Paula

Hiten D. Mistry

Bartira Ercília Pinheiro da Costa

Carlos Eduardo Poli-de-Figueiredo


Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE).
Methods: Case-control study conducted at São Lucas Hospital. Endocan-1 and PlGF levels were quantified in maternal plasma using MagPlexTH-C microspheres system and analysed by ANCOVA adjusted by BMI, gestational age and maternal age. To estimate the difference between groups, mean ratio (MR) and 95% confidence interval (CI) were calculated. Pearson correlation test was used to establish any association between Endocan-1 and PlGF levels. The null hypothesis was rejected when p

Journal Article Type Article
Publication Date Oct 31, 2018
Print ISSN 0100-7203
Electronic ISSN 1806-9339
Publisher Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Peer Reviewed Peer Reviewed
Volume 40
Issue 10
Pages 593-598
APA6 Citation Hentchke, M. R., da Cunha Filho, E. V., Vieira, M. C., Paula, L. G., Mistry, H. D., Pinheiro da Costa, B. E., & Poli-de-Figueiredo, C. E. (2018). Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia. Revista Brasileira de Ginecologia e Obstetrícia, 40(10), 593-598. doi:10.1055/s-0038-1670713
Keywords Pregnancy-induced hypertension; Preeclampsia; Endothelial function; Biomarkers; Preeclampsia, cytokines
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