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Stability of membrane bound reactions

Thul, Ruediger; Falcke, Martin

Authors

Martin Falcke



Abstract

We present a novel approach to the dynamics of reactions of diffusing chemical species with species fixed in space e.g. by binding to a membrane. The non-diffusing reaction partners are clustered in areas with a diameter smaller than the diffusion length of the diffusing partner. The activated fraction of the fixed species determines the size of an active sub-region of the cluster. Linear stability analysis reveals that diffusion is one of the ma jor determinants of the stability of the dynamics. We illustrate the model concept with Ca²⁺ dynamics in living cells, which has release channels as fixed reaction partners. Our results suggest that spatial and temporal structures in intracellular Ca²⁺ dynamics are caused by fluctuations due to the small number of channels per cluster.

Citation

Thul, R., & Falcke, M. (2004). Stability of membrane bound reactions. Physical Review Letters, 93(18), doi:10.1103/ PhysRevLet t.93.188103

Journal Article Type Article
Publication Date Jan 1, 2004
Deposit Date Nov 19, 2008
Publicly Available Date Nov 19, 2008
Journal Physical Review Letters
Print ISSN 0031-9007
Electronic ISSN 0031-9007
Publisher American Physical Society
Peer Reviewed Peer Reviewed
Volume 93
Issue 18
DOI https://doi.org/10.1103/+PhysRevLet+t.93.188103
Public URL http://eprints.nottingham.ac.uk/id/eprint/998
Publisher URL http://prola.aps.org/pdf/PRL/v93/i18/e188103
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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