Stability of membrane bound reactions

Thul, Ruediger; Falcke, Martin

Abstract

We present a novel approach to the dynamics of reactions of diffusing chemical species with species fixed in space e.g. by binding to a membrane. The non-diffusing reaction partners are clustered in areas with a diameter smaller than the diffusion length of the diffusing partner. The activated fraction of the fixed species determines the size of an active sub-region of the cluster. Linear stability analysis reveals that diffusion is one of the ma jor determinants of the stability of the dynamics. We illustrate the model concept with Ca²⁺ dynamics in living cells, which has release channels as fixed reaction partners. Our results suggest that spatial and temporal structures in intracellular Ca²⁺ dynamics are caused by fluctuations due to the small number of channels per cluster.

Citation

Thul, R., & Falcke, M. (2004). Stability of membrane bound reactions. Physical Review Letters, 93(18), doi:10.1103/ PhysRevLet t.93.188103

• Journal Article Type: Article
• Publication Date: Jan 1, 2004
• Deposit Date: Nov 19, 2008
• Publicly Available Date: Nov 19, 2008
• Journal: Physical Review Letters
• Print ISSN: 0031-9007
• Electronic ISSN: 0031-9007
• Publisher: American Physical Society
• Peer Reviewed: Peer Reviewed
• Volume: 93
• Issue: 18
• DOI: https://doi.org/10.1103/+PhysRevLet+t.93.188103
• Public URL: http://eprints.nottingham.ac.uk/id/eprint/998
• Publisher URL: http://prola.aps.org/pdf/PRL/v93/i18/e188103
• Copyright Statement: Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf