Yulia Timofeeva
Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework
Timofeeva, Yulia; Lord, Gabriel; Coombes, Stephen
Authors
Gabriel Lord
Professor STEPHEN COOMBES STEPHEN.COOMBES@NOTTINGHAM.AC.UK
Professor of Applied Mathematics
Abstract
The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded in a simple one-dimensional cable. This system is shown to support saltatory waves as a result of the discrete distribution of spines. Moreover, we demonstrate one of the ways to incorporate noise into the spine-head whilst retaining computational tractability of the model. The SDS model sustains a variety of propagating patterns.
Citation
Timofeeva, Y., Lord, G., & Coombes, S. (2005). Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework
Journal Article Type | Article |
---|---|
Publication Date | Oct 1, 2005 |
Deposit Date | Oct 24, 2005 |
Publicly Available Date | Oct 9, 2007 |
Peer Reviewed | Peer Reviewed |
Keywords | spike-diffuse-spike, dendritic spines, saltatory waves, noise |
Public URL | https://nottingham-repository.worktribe.com/output/1019914 |
Files
CNS2005.pdf
(464 Kb)
PDF
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