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Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework

Timofeeva, Yulia; Lord, Gabriel; Coombes, Stephen

Authors

Yulia Timofeeva

Gabriel Lord



Abstract

The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded in a simple one-dimensional cable. This system is shown to support saltatory waves as a result of the discrete distribution of spines. Moreover, we demonstrate one of the ways to incorporate noise into the spine-head whilst retaining computational tractability of the model. The SDS model sustains a variety of propagating patterns.

Journal Article Type Article
Publication Date Oct 1, 2005
Peer Reviewed Peer Reviewed
APA6 Citation Timofeeva, Y., Lord, G., & Coombes, S. (2005). Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework
Keywords spike-diffuse-spike, dendritic spines, saltatory waves, noise
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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CNS2005.pdf (464 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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