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Building oscillations bottom up: Elemental time scales of intracellular calcium dynamics

Thul, Ruediger; Falcke, Martin

Building oscillations bottom up: Elemental time scales of intracellular calcium dynamics Thumbnail


Authors

Martin Falcke



Contributors

Lutz Schimansky-Geier
Editor

Bernold Fiedler
Editor

J�rgen Kurths
Editor

Eckehard Sch�ll
Editor

Abstract

We analyze the elemental time scale of intracellular calcium dynamics. It is determined by the time course of Ca2+ puffs, which represent the fundamental quantum of Ca2+ release from intracellular storage compartments. Since Ca2+ puffs are truly random, we propose a novel master equation and corresponding Fokker-Planck equations. Our results demonstrate that puff initiation can be mapped to an escape process. The stochastic fraction of puff periods is identified with mean first passage times. We find that the discrete character of release sites represents a necessary condition for puff initiation. A continuous modeling of the number of open channels does not allow Ca2+ puffs in the relevant part of the parameter space.

Publication Date 2007-01
Deposit Date Jan 7, 2013
Publicly Available Date Jan 7, 2013
Peer Reviewed Peer Reviewed
Issue 5
Pages 293-324
Series Title World Scientific lecture notes in complex systems
Book Title Analysis and control of complex nonlinear processes in physics, chemistry and biology
ISBN 9789812705839
DOI https://doi.org/10.1142/9789812706911_0011
Public URL https://nottingham-repository.worktribe.com/output/1017038
Publisher URL http://www.worldscientific.com/doi/abs/10.1142/9789812706911_0011
Additional Information From: Analysis and control of complex nonlinear processes in physics, chemistry and biology, L. Schimansky-Geier, B. Fiedler, J. Kurths, E. Schöll (editors), Copyright @ 2007,
World Scientific. With permission from World Scientific Publishing Co. Pte. Ltd.

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