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System dynamics modelling of the processes involving the maintenance of the naive T cell repertoire

Figueredo, Grazziela P.; Aickelin, Uwe; Whitbrook, Amanda

Authors

Grazziela P. Figueredo gzf@cs.nott.ac.uk

Uwe Aickelin uwe.aickelin@nottingham.ac.uk

Amanda Whitbrook amw@cs.nott.ac.uk



Abstract

The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immuno-degradation that indicate signs of functionality loss possibly leading to death. Even though it is not possible to prevent immunosenescence, there is great benefit in comprehending its causes, which may help to reverse some of the damage done and thus improve life expectancy. One of the main factors influencing the process of immunosenescence is the number and phenotypical variety of naive T cells in an individual. This work presents a review of immunosenescence, proposes system dynamics modelling of the processes involving the maintenance of the naive T cell
repertoire and presents some preliminary results.

Peer Reviewed Peer Reviewed
Book Title Proceedings of the 9th Annual Workshop on Computational Intelligence (UKCI 2009), Nottingham, UK
APA6 Citation Figueredo, G. P., Aickelin, U., & Whitbrook, A. System dynamics modelling of the processes involving the maintenance of the naive T cell repertoire. In Proceedings of the 9th Annual Workshop on Computational Intelligence (UKCI 2009), Nottingham, UKIntelligent Modelling & Analysis (IMA)
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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