System dynamics modelling of the processes involving the maintenance of the naive T cell repertoire

Figueredo, Grazziela P.; Aickelin, Uwe; Whitbrook, Amanda

Abstract

The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immuno-degradation that indicate signs of functionality loss possibly leading to death. Even though it is not possible to prevent immunosenescence, there is great benefit in comprehending its causes, which may help to reverse some of the damage done and thus improve life expectancy. One of the main factors influencing the process of immunosenescence is the number and phenotypical variety of naive T cells in an individual. This work presents a review of immunosenescence, proposes system dynamics modelling of the processes involving the maintenance of the naive T cell
repertoire and presents some preliminary results.

Citation

Figueredo, G. P., Aickelin, U., & Whitbrook, A. System dynamics modelling of the processes involving the maintenance of the naive T cell repertoire. In Proceedings of the 9th Annual Workshop on Computational Intelligence (UKCI 2009), Nottingham, UK. Intelligent Modelling & Analysis (IMA)

• Deposit Date: Feb 2, 2012
• Peer Reviewed: Peer Reviewed
• Book Title: Proceedings of the 9th Annual Workshop on Computational Intelligence (UKCI 2009), Nottingham, UK
• Public URL: https://nottingham-repository.worktribe.com/output/1014373