Renata Retkute
Dynamics of DNA replication in yeast
Retkute, Renata; Nieduszynski, Conrad A.; Moura, Alessandro de
Authors
Conrad A. Nieduszynski
Alessandro de Moura
Abstract
We present a mathematical model for the spatial dynamics of DNA replication. Using this model we determine the probability distribution for the time at which each chromosomal position is replicated. From this we show, contrary to previous reports, that mean replication time curves cannot be used to directly determine origin parameters. We demonstrate that the stochastic nature of replication dynamics leaves a clear signature in experimentally measured population average data, and we show that the width of the activation time probability distribution can be inferred from this data. Our results compare favorably with experimental measurements in Saccharomyces cerevisae.
Citation
Retkute, R., Nieduszynski, C. A., & Moura, A. D. (2011). Dynamics of DNA replication in yeast. Physical Review Letters, 107, Article 068103. https://doi.org/10.1103/PhysRevLett.107.068103
Journal Article Type | Article |
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Publication Date | Aug 1, 2011 |
Deposit Date | Apr 1, 2014 |
Publicly Available Date | Apr 1, 2014 |
Journal | Physical Review Letters |
Print ISSN | 0031-9007 |
Electronic ISSN | 0031-9007 |
Publisher | American Physical Society |
Peer Reviewed | Peer Reviewed |
Volume | 107 |
Article Number | 068103 |
DOI | https://doi.org/10.1103/PhysRevLett.107.068103 |
Public URL | https://nottingham-repository.worktribe.com/output/1009799 |
Publisher URL | http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.107.068103 |
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Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0