Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer

Storr, Sarah J.; Safuan, Sabreena; Woolston, Caroline M.; Abdel-Fatah, Tarek; Deen, Suha; Chan, Stephen Y.; Martin, Stewart G.

Abstract

Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy
regimen and the ability to identify those patients at risk of developing resistance is of considerable clinical importance. The expression of
calpain-1, calpain-2 and calpastatin were determined using standard immunohistochemistry on a tissue microarray of 154 primary ovarian carcinomas
from patients subsequently treated with platinum-based adjuvant chemotherapy. High levels of calpain-2 expression was significantly associated
with platinum resistant tumours (P = 0.031). Furthermore, high expression of calpain-2 was significantly associated with progression-free
(P = 0.049) and overall survival (P = 0.006) in this cohort. The association between calpain-2 expression and overall survival remained significant
in multivariate analysis accounting for tumour grade, stage, optimal debulking and platinum sensitivity (hazard ratio = 2.174; 95% confidence
interval = 1.144–4.130; P = 0.018). The results suggest that determining calpain-2 expression in ovarian carcinomas may allow prognostic stratification
of patients treated with surgery and platinum-based chemotherapy. The findings of this study warrant validation in a larger clinical cohort.

Citation

Storr, S. J., Safuan, S., Woolston, C. M., Abdel-Fatah, T., Deen, S., Chan, S. Y., & Martin, S. G. (2012). Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. Journal of Cellular and Molecular Medicine, 16(10), https://doi.org/10.1111/j.1582-4934.2012.01559.x

• Journal Article Type: Article
• Publication Date: Oct 1, 2012
• Deposit Date: Apr 1, 2014
• Publicly Available Date: Apr 1, 2014
• Journal: Journal of Cellular and Molecular Medicine
• Print ISSN: 1582-1838
• Electronic ISSN: 1582-1838
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 10
• DOI: https://doi.org/10.1111/j.1582-4934.2012.01559.x
• Public URL: https://nottingham-repository.worktribe.com/output/1006539
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01559.x/abstract
• Additional Information: Published source must be acknowledged including article DOI