Skip to main content

Research Repository

Advanced Search

Outputs (7)

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes. (2023)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., …Smyth, A. R. (2023). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes. NIHR Open Research, 3(65), 1-16. https://doi.org/10.3310/nihropenres.13510.1

Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung fun... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes..

Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging (2021)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C. L., Marciani, L., Ban, L., Prayle, A. P., …Smyth, A. R. (2021). Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging. Journal of Cystic Fibrosis, 20(4), 591-597. https://doi.org/10.1016/j.jcf.2020.06.004

Background: Cystic fibrosis (CF) is a multi-system genetic disorder affecting >72,000 people worldwide. Most CF patients experience gastrointestinal symptoms and can develop complications. However, the mechanisms of CF gut disease are not well unders... Read More about Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging.

Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging (2018)
Journal Article
Major, G., Murray, K., Singh, G., Nowak, A., Hoad, C. L., Marciani, L., …Spiller, R. C. (2018). Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging. Neurogastroenterology and Motility, 30(9), Article e13400. https://doi.org/10.1111/nmo.13400

Background: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of Magnetic Resonance Imaging (MRI) for this task using psyllium, an effective constip... Read More about Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging.

Assessment of motion of colonic contents in the human colon using MRI tagging (2017)
Journal Article
Pritchard, S. E., Paul, J., Major, G., Marciani, L., Gowland, P. A., Spiller, R. C., & Hoad, C. (2017). Assessment of motion of colonic contents in the human colon using MRI tagging. Neurogastroenterology and Motility, 29(9), Article e13091. https://doi.org/10.1111/nmo.13091

Background We have previously reported a non-invasive, semi-automated technique to assess motility of the wall of the ascending colon (AC) using Magnetic Resonance Imaging. This study investigated the feasibility of using a tagged MRI technique to vi... Read More about Assessment of motion of colonic contents in the human colon using MRI tagging.

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome (2016)
Journal Article
Major, G., Pritchard, S. E., Murray, K., Alappadan, J. P., Hoad, C., Marciani, L., …Spiller, R. C. (2017). Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome. Gastroenterology, 152(1), 124-133.e2. https://doi.org/10.1053/j.gastro.2016.09.062

Background & Aims: Poorly digested, fermentable carbohydrates may induce symptoms of irritable bowel syndrome (IBS), via unclear mechanisms. We performed a randomized trial with magnetic resonance imaging (MRI) analysis to investigate correlations be... Read More about Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.

Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI (2015)
Journal Article
Hoad, C., Menys, A., Garsed, K., Marciani, L., Hamy, V., Murray, K., …Gowland, P. A. (2016). Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI. Neurogastroenterology and Motility, 28(3), 327-335. https://doi.org/10.1111/nmo.12727

Background Recently, cine magnetic resonance imaging (MRI) has shown promise for visualizing movement of the colonic wall, although assessment of data has been subjective and observer dependent. This study aimed to develop an objective and semi-au... Read More about Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI.