Outputs (1290)

The mechanisms of nanoparticle internalization and transport across an intestinal epithelial cell model: effect of size and surface charge (2014)
Journal Article
Bannunah, A. M., Vllasaliu, D., Lord, J., & Stolnik, . S. (2014). The mechanisms of nanoparticle internalization and transport across an intestinal epithelial cell model: effect of size and surface charge. Molecular Pharmaceutics, 11(12), 4363-4373. doi:10.1021/mp500439c

This study investigated the effect of nanoparticle size (50 and 100 nm) and surface charge on their interaction with Caco-2 monolayers as a model of the intestinal epithelium, including cell internalization pathways and the level of transepithelial t... Read More about The mechanisms of nanoparticle internalization and transport across an intestinal epithelial cell model: effect of size and surface charge.

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor (2014)
Journal Article
Abdul-Ridha, A., Lane, J. R., Mistry, S. N., Lopez, L., Sexton, P. M., Scammells, P. J., …Canals, M. (2014). Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor. Journal of Biological Chemistry, 289(48), 33701-33711. https://doi.org/10.1074/jbc.m114.604967

Benzylquinolone carboxylic acid (BQCA) is the first highly selective positive allosteric modulator (PAM) for the M1 muscarinic acetylcholine receptor (mAChR), but it possesses low affinity for the allosteric site on the receptor. More recent drug dis... Read More about Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor.

Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions (2014)
Journal Article
Meeus, J., Scurr, D. J., Chen, X., Amssoms, K., Davies, M. C., Roberts, C. J., & Mooter, G. V. D. (2015). Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions. Pharmaceutical Research, 32(4), 1407-1416. https://doi.org/10.1007/s11095-014-1543-8

Purpose: Miscibility of the different compounds that make up a solid dispersion based formulation play a crucial role in the drug release profile and physical stability of the solid dispersion as it defines the phase behaviour of the dispersion. The... Read More about Combination of (M)DSC and Surface Analysis to Study the Phase Behaviour and Drug Distribution of Ternary Solid Dispersions.

Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI) (2014)
Journal Article
Barker, J., Reid, J., Snape, C., Scurr, D., & Meredith, W. (2014). Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI). SAE International Journal of Fuels and Lubricants, 7(3), 762-770. https://doi.org/10.4271/2014-01-2720

Copyright © 2014 SAE International. Since 2009, there has been a rise in deposits of various types found in diesel fuel injection systems. They have been identified in the filter, the injector tip and recently inside the injector. The latter internal... Read More about Spectroscopic Studies of Internal Injector Deposits (IDID) Resulting from the Use of Non-Commercial Low Molecular Weight Polyisobutylenesuccinimide (PIBSI).

Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry (2014)
Journal Article
Montowska, M., Alexander, M. R., Tucker, G. A., & Barrett, D. A. (2014). Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry. Analytical Chemistry, 86(20), 10257-10265. https://doi.org/10.1021/ac502449w

In this paper, our previously developed ambient LESA-MS methodology is implemented to analyze five types of thermally treated meat species, namely beef, pork, horse, chicken, and turkey meat, in order to select and identify heat-stable and species-sp... Read More about Rapid Detection of Peptide Markers for Authentication Purposes in Raw and Cooked Meat Using Ambient Liquid Extraction Surface Analysis Mass Spectrometry.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors (2014)
Journal Article
Mistry, S. N., Drinkwater, N., Ruggeri, C., Sivaraman, K. K., Loganathan, S., Fletcher, S., …McGowan, S. (2014). Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors. Journal of Medicinal Chemistry, 57(21), https://doi.org/10.1021/jm501323a

Plasmodium parasites, the causative agents of malaria, have developed resistance to most of our current antimalarial therapies, including artemisinin combination therapies which are widely described as our last line of defense. Antimalarial agents wi... Read More about Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model (2014)
Journal Article
Sidney, L. E., Heathman, T. R., Britchford, E., Abed, A. A., Rahman, C. V., & Buttery, L. D. (2015). Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model. Tissue Engineering: Parts A, B, and C, 21(1-2), 362-373. https://doi.org/10.1089/ten.tea.2014.0100

Nonunion fractures and large bone defects are significant targets for osteochondral tissue engineering strategies. A major hurdle in the use of these therapies is the foreign body response of the host. Herein, we report the development of a bone tiss... Read More about Investigation of Localized Delivery of Diclofenac Sodium from Poly(D,L-Lactic Acid-co-Glycolic Acid)/Poly(Ethylene Glycol) Scaffolds Using an In Vitro Osteoblast Inflammation Model.

The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia (2014)
Journal Article
Lai, P. S. M., Toh, L. S., Wong, K. T., Tan, A. T. B., Low, B. Y., Anderson, C., & Bin-Chia, D. W. (2014). The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia. Patient Preference and Adherence, 8, 1365- 1381. doi:10.2147/ppa.s65718

Purpose: To develop and validate the English version of the Satisfaction Questionnaire for Osteoporosis Prevention (SQOP) in Malaysia. Methods: The SQOP was modified from the Osteoporosis Patient Satisfaction Questionnaire and developed based on l... Read More about The development and validation of the Satisfaction Questionnaire for Osteoporosis Prevention in Malaysia.

Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations (2014)
Journal Article
Sawbridge, J. L., Qureshi, H. K., Boyd, M. J., & Brown, A. M. (2014). Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations. Advances in Physiology Education, 38(3), 239-245. https://doi.org/10.1152/advan.00036.2014

The ability to understand and implement calculations required for molarity and dilution computations that are routinely undertaken in the laboratory are essential skills that should be possessed by all students entering an undergraduate Life Sciences... Read More about Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations.

Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides (2014)
Journal Article
Krishna Mohan Nalluri, S., Shivarova, N., Kanibolotsky, A. L., Zelzer, M., Gupta, S., Frederix, P. W., …Ulijn, R. V. (2014). Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides. Langmuir, 30(41), 12429-12437. https://doi.org/10.1021/la503459y

We demonstrate the nonaqueous self-assembly of a low-molecular-mass organic gelator based on an electroactive p-type tetrathiafulvalene (TTF)–dipeptide bioconjugate. We show that a TTF moiety appended with diphenylalanine amide derivative (TTF-FF-NH2... Read More about Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides.