Outputs (111)

Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices (2021)
Journal Article
He, Y., Luckett, J., Begines, B., Dubern, J. F., Hook, A. L., Prina, E., …Wildman, R. D. (2022). Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices. Biomaterials, 281, Article 121350. https://doi.org/10.1016/j.biomaterials.2021.121350

Chronic infection as a result of bacterial biofilm formation on implanted medical devices is a major global healthcare problem requiring new biocompatible, biofilm-resistant materials. Here we demonstrate how bespoke devices can be manufactured throu... Read More about Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices.

The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections (2021)
Journal Article
Needham, D. (2022). The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections. Pharmaceutical Research, 39(1), 115-141. https://doi.org/10.1007/s11095-021-03112-x

Motivation: With the coronavirus pandemic still raging, prophylactic-nasal and early-treatment throat-sprays could help prevent infection and reduce viral load. Niclosamide has the potential to treat a broad-range of viral infections if local bioavai... Read More about The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections.

National pharmacy associations in the commonwealth: current scenario and future needs to maximise effective contributions of the pharmacy profession towards universal health coverage (2021)
Journal Article
Iqbal, A., Rutter, V., Gülpınar, G., Halai, M., Awele, B., Elshenawy, R. A., …Chan, A. H. Y. (2021). National pharmacy associations in the commonwealth: current scenario and future needs to maximise effective contributions of the pharmacy profession towards universal health coverage. Journal of Pharmaceutical Policy and Practice, 14(1), Article 112. https://doi.org/10.1186/s40545-021-00396-7

Background The Commonwealth Pharmacists Association (CPA) is a charity representing pharmacists across the Commonwealth, with the vision of empowering and collaboratively develop the profession and fully utilise the potential of pharmacists to stren... Read More about National pharmacy associations in the commonwealth: current scenario and future needs to maximise effective contributions of the pharmacy profession towards universal health coverage.

Immune-instructive materials as new tools for immunotherapy (2021)
Journal Article
Fisher, L. E., Kämmerling, L., Alexander, M. R., & Ghaemmaghami, A. M. (2022). Immune-instructive materials as new tools for immunotherapy. Current Opinion in Biotechnology, 74, 194-203. https://doi.org/10.1016/j.copbio.2021.11.005

Immune instructive materials, are materials with the ability to modulate or mimic the function of immune cells, provide exciting opportunities for developing new therapies in many areas including medical devices, chronic inflammation, cancer, and aut... Read More about Immune-instructive materials as new tools for immunotherapy.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Treadwell, K., Roach, P., Morgan, R., Lodge, R., Hyland, M., …Kehoe, O. (2022). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), Article 126. https://doi.org/10.3390/ijms23010126

Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs in an an... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

The influence of printing parameters on multi-material two-photon polymerisation based micro additive manufacturing (2021)
Journal Article
Hu, Q., Rance, G. A., Trindade, G. F., Pervan, D., Jiang, L., Foerster, A., …Wildman, R. D. (2022). The influence of printing parameters on multi-material two-photon polymerisation based micro additive manufacturing. Additive Manufacturing, 51, Article 102575. https://doi.org/10.1016/j.addma.2021.102575

Two-photon polymerisation (2PP) based additive manufacturing has emerged as a powerful technology to fabricate complex three-dimensional micro- and nanoscale architectures. However, a comprehensive understanding of the effect of printing parameters o... Read More about The influence of printing parameters on multi-material two-photon polymerisation based micro additive manufacturing.

Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes (2021)
Journal Article
Ghosh, M., Majkowska, A., Mirsa, R., Bera, S., Rodríguez-Cabello, J. C., Mata, A., & Adler-Abramovich, L. (2022). Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes. ACS Applied Materials and Interfaces, 14(1), 464-473. https://doi.org/10.1021/acsami.1c22136

Molecular self-assembly is a spontaneous natural process resulting in highly ordered nano to microarchitectures. We report temperature-independent formation of robust stable membranes obtained by the spontaneous interaction of intrinsically disordere... Read More about Disordered Protein Stabilization by Co-Assembly of Short Peptides Enables Formation of Robust Membranes.

FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer (2021)
Journal Article
Larsson, P. F., Karlsson, R., Sarwar, M., Miftakhova, R., Wang, T., Syed Khaja, A. S., …Persson, J. L. (2022). FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer. Molecular Oncology, https://doi.org/10.1002/1878-0261.13166

Low-affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) is a cell surface protein that belongs to a family of Fc receptors that facilitate the protective function of the immune system against pathogens. However, the role of FcγRIIIa in... Read More about FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer.

Engineering bacteria to control electron transport altering the synthesis of non-native polymer (2021)
Journal Article
Bennett, M. R., Jain, A., Kovacs, K., Hill, P. J., Alexander, C., & Rawson, F. J. (2021). Engineering bacteria to control electron transport altering the synthesis of non-native polymer. RSC Advances, 12, 451-457. https://doi.org/10.1039/d1ra06403g

The use of bacteria as catalysts for radical polymerisations of synthetic monomers has recently been established. However, the role of trans Plasma Membrane Electron Transport (tPMET) in modulating these processes is not well understood. We sort to s... Read More about Engineering bacteria to control electron transport altering the synthesis of non-native polymer.

Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements (2021)
Journal Article
Zhang, Q., Pavanello, L., Potapov, A., Bartlam, M., & Winkler, G. S. (2022). Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements. Protein Science, 31(3), 758-764. https://doi.org/10.1002/pro.4262

Regulated degradation of mature, cytoplasmic mRNA is a key step in eukaryotic gene regulation. This process is typically initiated by the recruitment of deadenylase enzymes by cis-acting elements in the 3' untranslated region resulting in the shorten... Read More about Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements.