Outputs (133)

Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective (2018)
Journal Article
Garces, A. E., & Stocks, M. J. (2019). Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective. Journal of Medicinal Chemistry, 62(10), 4815-4850. https://doi.org/10.1021/acs.jmedchem.8b01492

Phosphatidylinositol 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3-OH of the inositol ring of phosphoinositides, and deregulation of this pathway has implications in many diseases. The search for novel PI3K inhibitors has b... Read More about Class 1 PI3K clinical candidates and recent inhibitor design strategies: a medicinal chemistry perspective.

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article
Rose, J., Sidney, L., Patient, J., White, L., Dua, H., El Haj, A., …Rose, F. (2018). In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft. Journal of Biomedical Materials Research Part A, 107(4), 828-838. https://doi.org/10.1002/jbm.a.36598

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.

Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique (2018)
Journal Article
Mehta, P., Al-Kinani, A. A., Qutachi, O., Arshad, M. S., Alqahtani, A., Chang, M., …Ahmad, Z. (2019). Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique. Journal of Physics: Materials, 2(1), 1-7. https://doi.org/10.1088/2515-7639/aaf263

In vitro testing alone is no longer considered sufficient evidence presented solely with respect to drug release and permeation testing. These studies are thought to be more reliable and representative when using tissue or animal models; as opposed t... Read More about Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique.

Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS (2018)
Journal Article
Dahabiyeh, L. A., Tooth, D., & Barrett, D. A. (2019). Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS. Analytical Biochemistry, 567, 72-81. https://doi.org/10.1016/j.ab.2018.12.011

Glycoproteins play a central role in diverse biological processes and are linked with many serious human diseases. In this paper we present a simple, reproducible and cost-effective analytical workflow that enables the reliable quantification of clin... Read More about Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS.

The pharmacy care plan service: Evaluation and estimate of cost-effectiveness (2018)
Journal Article
Twigg, M. J., Wright, D., Barton, G., Kirkdale, C. L., & Thornley, T. (2019). The pharmacy care plan service: Evaluation and estimate of cost-effectiveness. Research in Social and Administrative Pharmacy, 15(1), 84-92. https://doi.org/10.1016/j.sapharm.2018.03.062

Background: The UK Community Pharmacy Future group developed the Pharmacy Care Plan (PCP) service with a focus on patient activation, goal setting and therapy management. Objective: To estimate the effectiveness and cost-effectiveness of the PCP... Read More about The pharmacy care plan service: Evaluation and estimate of cost-effectiveness.

Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site (2018)
Journal Article
Li, W., Sun, H., Xu, F., Shuai, W., Liu, J., Xu, S., …Xu, J. (2019). Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site. Bioorganic Chemistry, 85, 49-59. https://doi.org/10.1016/j.bioorg.2018.12.015

Twenty-two novel indole-vinyl sulfone derivatives were designed, synthesized and evaluated as tubulin polymerization inhibitors. The physicochemical and drug-likeness properties of all target compounds were predicted by Osiris calculations. All compo... Read More about Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site.

Geometry alone influences stem cell differentiation in a precision 3D printed stem cell niche (2018)
Working Paper
Prina, E., Sidney, L., Tromayer, M., Moore, J., Liska, R., Bertolin, M., …Rose, F. R. Geometry alone influences stem cell differentiation in a precision 3D printed stem cell niche

Stem cells within epithelial tissues reside in anatomical structures known as crypts that are known to contribute to the mechanical and chemical milieu important for function. To date, epithelial stem cell therapies have largely ignored the niche and... Read More about Geometry alone influences stem cell differentiation in a precision 3D printed stem cell niche.

Hydrophobicity of surface-immobilised molecules influences architectures formed via interfacial self-assembly of nucleoside-based gelators (2018)
Journal Article
Angelerou, M. G. F., Yang, B., Arnold, T., Rawle, J., Marlow, M., & Zelzer, M. (2018). Hydrophobicity of surface-immobilised molecules influences architectures formed via interfacial self-assembly of nucleoside-based gelators. Soft Matter, 14(48), 9851-9855. https://doi.org/10.1039/c8sm01868e

Surface-mediated self-assembly has potential in biomaterial development but underlying rules governing surface-gelator interactions are poorly understood. Here, we correlate surface properties with structural characterization data of nucleoside-based... Read More about Hydrophobicity of surface-immobilised molecules influences architectures formed via interfacial self-assembly of nucleoside-based gelators.

Qualitative study using interviews and focus groups to explore the current and potential for antimicrobial stewardship in community pharmacy informed by the Theoretical Domains Framework (2018)
Journal Article
Jones, L. F., Owens, R., Sallis, A., Ashiru-Oredope, D., Thornley, T., Francis, N. A., …McNulty, C. A. (2018). Qualitative study using interviews and focus groups to explore the current and potential for antimicrobial stewardship in community pharmacy informed by the Theoretical Domains Framework. BMJ Open, 8(12), Article e025101. https://doi.org/10.1136/bmjopen-2018-025101

Objectives Community pharmacists and their staff have the potential to contribute to antimicrobial stewardship (AMS). However, their barriers and opportunities are not well understood. The aim was to investigate the experiences and perceptions of com... Read More about Qualitative study using interviews and focus groups to explore the current and potential for antimicrobial stewardship in community pharmacy informed by the Theoretical Domains Framework.

Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site (2018)
Journal Article
Li, W., Shuai, W., Sun, H., Xu, F., Bi, Y., Xu, J., …Xu, S. (2019). Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site. European Journal of Medicinal Chemistry, 163, 428-442. https://doi.org/10.1016/j.ejmech.2018.11.070

A series of novel isocombretastatin A-4 (isoCA-4) analogs were designed and synthesized by replacing 3,4,5-trimethoylphenyl and isovanillin of isoCA-4 with quinoline and indole moieties, respectively. The structure activity relationships (SARs) of th... Read More about Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.