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Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group (2017)
Journal Article
Perego, P., Hempel, G., Linder, S., Bradshaw, T. D., Larsen, A. K., Peters, G. J., & Phillips, R. M. (in press). Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group. Cancer Chemotherapy and Pharmacology, https://doi.org/10.1007/s00280-017-3502-7

An increasing number of manuscripts focus on the in vitro evaluation of established and novel anti-tumour agents in experimental models. Whilst the design of such in vitro assays is inherently flexible, some of these studies lack the minimum informat... Read More about Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group.

Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding (2017)
Journal Article
Purdie, L., Alexander, C., Spain, S. G., & Magnusson, J. P. (2018). Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding. Molecular Pharmaceutics, 15(2), https://doi.org/10.1021/acs.molpharmaceut.7b00805

DNA-based drug delivery vehicles have displayed promise for the delivery of intercalating drugs. Here, we demonstrate that oligonucleotides modified with an alkyl chain can bind to human serum albumin, mimicking the natural binding of fatty acids. Th... Read More about Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding.

Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis (2017)
Journal Article
Kay, A. G., Long, G., Tyler, G., Stefan, A., Broadfoot, S. J., Piccinini, A. M., …Kehoe, O. (2017). Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis. Scientific Reports, 7, Article 18019. https://doi.org/10.1038/s41598-017-18144-w

We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease severity and cartilage loss were evaluated by histopathological anal... Read More about Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis.

An augmented delivery of the anticancer agent, curcumin, to the colon (2017)
Journal Article
Sabra, R., Billa, N., & Roberts, C. J. (2018). An augmented delivery of the anticancer agent, curcumin, to the colon. Reactive and Functional Polymers, 123, https://doi.org/10.1016/j.reactfunctpolym.2017.12.012

This work describes the formulation aspects of an orally viable curcumin-containing mucoadhesive nanoparticulate system for management of colon cancer. Curcumin is documented to possess anticancer properties whilst modified citrus pectin yields a gal... Read More about An augmented delivery of the anticancer agent, curcumin, to the colon.

The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells (2017)
Journal Article
Schlosser, M., Löser, H., Siegmund, S. V., Montesinos-Rongen, M., Bindila, L., Lutz, B., …Fries, J. W. (2017). The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells. CellBio, 6(4), 35-55. https://doi.org/10.4236/cellbio.2017.64004

Background: The endocannabinoid (EC) system is well characterized in the central nervous system but scarcely studied in peripheral organs. In this paper, we newly identify the effect of the EC anandamide (AEA) upon renal proximal tubule cells. Meth... Read More about The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells.

Enhancing cell and gene therapy manufacture through the application of advanced fluorescent optical sensors (Review) (2017)
Journal Article
Harrison, R. P., & Chauhan, V. M. (2018). Enhancing cell and gene therapy manufacture through the application of advanced fluorescent optical sensors (Review). Biointerphases, 13(1), Article 01A301-1-01A301-8. https://doi.org/10.1116/1.5013335

Cell and gene therapies (CGTs) are examples of future therapeutics that can be used to cure or alleviate the symptoms of disease, by repairing damaged tissue or reprogramming defective genetic information. However, despite the recent advancements in... Read More about Enhancing cell and gene therapy manufacture through the application of advanced fluorescent optical sensors (Review).

Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography (2017)
Journal Article
Yang, J., Shakesheff, K. M., & Prasopthum, A. (2018). Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography. Biofabrication, 10(2), Article 025002. https://doi.org/10.1088/1758-5090/aaa15b

Three-dimensional (3D) printing is a powerful manufacturing tool for making 3D structures with well-defined architectures for a wide range of applications. The field of tissue engineering has also adopted this technology to fabricate scaffolds for ti... Read More about Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography.

A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells (2017)
Journal Article
Arruda, M. A., Stoddart, L. A., Gherbi, K., Briddon, S. J., Kellam, B., & Hill, S. J. (in press). A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells. Frontiers in Pharmacology, 8(908), https://doi.org/10.3389/fphar.2017.00908

Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags. Here, we h... Read More about A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells.

Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells (2017)
Journal Article
Vining, K. H., Scherba, J. C., Bever, A., Alexander, M. R., Celiz, A. D., & Mooney, D. J. (2018). Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells. Advanced Materials, 30(4), Article 1704486. https://doi.org/10.1002/adma.201704486

Dental disease annually affects billions of patients, and while regenerative dentistry aims to heal dental tissue after injury, existing polymeric restorative materials, or fillings, do not directly participate in the healing process in a bioinstruct... Read More about Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells.

The physicochemical fingerprint of Necator americanus (2017)
Journal Article
Chauhan, V. M., Scurr, D. J., Christie, T., Telford, G., Aylott, J. W., & Pritchard, D. (in press). The physicochemical fingerprint of Necator americanus. PLoS Neglected Tropical Diseases, 11(12), Article e0005971. https://doi.org/10.1371/journal.pntd.0005971

Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world’s population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs... Read More about The physicochemical fingerprint of Necator americanus.