Skip to main content

Research Repository

Advanced Search

Outputs (103)

Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers (2016)
Journal Article
England, R. M., Hare, J. I., Barnes, J., Wilson, J., Smith, A., Strittmatter, N., …Ashford, M. B. (2017). Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers. Journal of Controlled Release, 247, https://doi.org/10.1016/j.jconrel.2016.12.034

Irinotecan is used clinically for the treatment of colorectal cancer; however, its utility is limited by its narrow therapeutic index. We describe the use of a generation 5 l-lysine dendrimer that has been part-modified with a polyoxazoline as a drug... Read More about Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers.

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults (2016)
Journal Article
Wiffen, P. J., Knaggs, R., Derry, S., Cole, P., Phillips, T., & Moore, R. A. (2016). Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD012227. https://doi.org/10.1002/14651858.CD012227.pub2

BACKGROUND Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies. OBJECTIVES To... Read More about Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.

The structural modification of natural products for novel drug discovery (2016)
Journal Article
Yao, H., Liu, J., Xu, S., Zhu, Z., & Xu, J. (in press). The structural modification of natural products for novel drug discovery. Expert Opinion on Drug Discovery, 12(2), https://doi.org/10.1080/17460441.2016.1272757

Introduction: Throughout history, natural products (NPs) have provided a rich source of compounds that have wide applications in the fields of medicine, health sciences, pharmacy and biology. Although naturally active substances are good lead compoun... Read More about The structural modification of natural products for novel drug discovery.

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile (2016)
Journal Article
van Eijk, E., Paschalis, V., Green, M., Friggen, A. H., Larson, M. A., Spriggs, K., …Smits, W. K. (2016). Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile. Open Biology, 6(12), Article 160272. https://doi.org/10.1098/rsob.160272

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of D... Read More about Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile.

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus (2016)
Journal Article
Zapotoczna, M., Murray, E. J., Hogan, S., O'Gara, J. P., Chhabra, S. R., Chan, W. C., …Williams, P. (2017). 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 72(3), 744-753. https://doi.org/10.1093/jac/dkw482

Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential of 5-hydroxyethyl-3-tetradec... Read More about 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.

The impact of detergents on the tissue decellularization process: a ToF-SIMS study (2016)
Journal Article
White, L. J., Taylor, A. J., Faulk, D. M., Keane, T. J., Saldin, L. T., Reing, J. E., …Badylak, S. F. (2017). The impact of detergents on the tissue decellularization process: a ToF-SIMS study. Acta Biomaterialia, 50, https://doi.org/10.1016/j.actbio.2016.12.033

Biologic scaffolds are derived from mammalian tissues, which must be decellularized to remove cellular antigens that would otherwise incite an adverse immune response. Although widely used clinically, the optimum balance between cell removal and the... Read More about The impact of detergents on the tissue decellularization process: a ToF-SIMS study.

Views on unwanted effects of leave-on emollients and experiences surrounding their incidence (2016)
Journal Article
Oakley, R., & Lawton, S. (2016). Views on unwanted effects of leave-on emollients and experiences surrounding their incidence. Dermatological Nursing, 15(4),

Background: The mainstay treatment for eczema is leave-on emollients. The aim of this study was to find out more about unwanted effects that have been reported with their use, as little is known due to a lack of formal reporting. Aims: To gain a g... Read More about Views on unwanted effects of leave-on emollients and experiences surrounding their incidence.

Do statin users adhere to a healthy diet and lifestyle?: the Australian Diabetes, Obesity and Lifestyle Study (2016)
Journal Article
Johal, S., Jamsen, K. M., Bell, S. J., McNamara, K. P., Magliano, D., Liew, D., …Ilomäki, J. (in press). Do statin users adhere to a healthy diet and lifestyle?: the Australian Diabetes, Obesity and Lifestyle Study. European Journal of Preventive Cardiology, https://doi.org/10.1177/2047487316684054

Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consum... Read More about Do statin users adhere to a healthy diet and lifestyle?: the Australian Diabetes, Obesity and Lifestyle Study.

Chemical intervention in plant sugar signalling increases yield and resilience (2016)
Journal Article
Griffiths, C. A., Sagar, R., Geng, Y., Primavesi, L. F., Patel, M. K., Passarelli, M. K., …Davis, B. G. (2016). Chemical intervention in plant sugar signalling increases yield and resilience. Nature, 540(7634), 574-578. https://doi.org/10.1038/nature20591

The pressing global issue of food insecurity due to population growth, diminishing land and variable climate can only be addressed in agriculture by improving both maximum crop yield potential and resilience. Genetic modification is one potential sol... Read More about Chemical intervention in plant sugar signalling increases yield and resilience.

Intercultural capability: exploring first year HE students' reflections on and experiences of their higher education experience (2016)
Conference Proceeding
Mullen, E., Eccles, S., Dippold, D., & Bridges, S. (2016). Intercultural capability: exploring first year HE students' reflections on and experiences of their higher education experience.

This round table discussion presents the initial stages of a cross-institution project exploring the reflections and expectations of first year international and home students. This study aims to capture students' early experiences in higher educatio... Read More about Intercultural capability: exploring first year HE students' reflections on and experiences of their higher education experience.