Outputs (37)

Protocol for the New Medicine Service Study: a randomized controlled trial and economic evaluation with qualitative appraisal comparing the effectiveness and cost effectiveness of the New Medicine Service in community pharmacies in England (2013)
Journal Article
Boyd, M., Waring, J., Barber, N., Mehta, R., Chuter, A., Avery, A., …Elliott, R. A. (2013). Protocol for the New Medicine Service Study: a randomized controlled trial and economic evaluation with qualitative appraisal comparing the effectiveness and cost effectiveness of the New Medicine Service in community pharmacies in England. Trials, 14(1), 411. https://doi.org/10.1186/1745-6215-14-411

Background Medication non-adherence is considered an important cause of morbidity and mortality in primary care. This study aims to determine the effectiveness, cost effectiveness and acceptability of a complex intervention delivered by community... Read More about Protocol for the New Medicine Service Study: a randomized controlled trial and economic evaluation with qualitative appraisal comparing the effectiveness and cost effectiveness of the New Medicine Service in community pharmacies in England.

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine (2013)
Journal Article
Walsby, E., Pratt, G., Shao, H., Abbas, A. Y., Fischer, P., Bradshaw, T. D., …Pepper, C. (2013). A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine. Oncotarget, 5, 375-385

Cdk9 is a key elongation factor for RNA transcription and functions by phosphorylating the C-terminal domain of RNA polymerase II. Here we present direct evidence that cdk9 is important for cancer cell survival and describe the characterization of th... Read More about A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine.

Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells (2013)
Journal Article
Bradshaw, T. D., Junor, M., Patanè, A., Clarke, P., Thomas, N. R., Li, M., …Turyanska, L. (2013). Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells. Journal of Materials Chemistry B, 45, 6254-6260. https://doi.org/10.1039/c3tb21197e

Colorectal carcinoma (CRC) is the 3rd most common cancer worldwide, thus development of novel therapeutic strategies is imperative. Herein potent, selective dose-dependent antitumor activity of horse spleen apoferritin encapsulated PbS quantum dots (... Read More about Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells.

Modelling and Prediction of Bacterial Attachment to Polymers (2013)
Journal Article
Epa, V., Hook, A. L., Chang, C., Yang, J., Langer, R., Anderson, D. G., …Winkler, D. A. (2014). Modelling and Prediction of Bacterial Attachment to Polymers. Advanced Functional Materials, 24(14), 2085-2093. https://doi.org/10.1002/adfm.201302877

Infection by pathogenic bacteria on implanted and indwelling medical devices during surgery causes large morbidity and mortality worldwide. Attempts to ameliorate this important medical issue have included development of antimicrobial surfaces on mat... Read More about Modelling and Prediction of Bacterial Attachment to Polymers.

Ambient DESI and LESA-MS analysis of proteins adsorbed to a biomaterial surface using in-situ surface tryptic digestion (2013)
Journal Article
Rao, W., Celiz, A. D., Scurr, D. J., Alexander, M. R., & Barrett, D. A. (2013). Ambient DESI and LESA-MS analysis of proteins adsorbed to a biomaterial surface using in-situ surface tryptic digestion. Journal of The American Society for Mass Spectrometry, 24(12), https://doi.org/10.1007/s13361-013-0737-3

The detection and identification of proteins adsorbed onto biomaterial surfaces under ambient conditions has significant experimental advantages but has proven to be difficult to achieve with conventional measuring technologies. In this study, we pre... Read More about Ambient DESI and LESA-MS analysis of proteins adsorbed to a biomaterial surface using in-situ surface tryptic digestion.

Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes (2013)
Journal Article
Lui, L. T., Xue, X., Sui, C., Brown, A., Pritchard, D. I., Halliday, N., …Alexander, C. (2013). Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes. Nature Chemistry, 5(12), https://doi.org/10.1038/nchem.1793

Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one mean by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can... Read More about Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes.

Development of a porous poly(DL-lactic acid-co-glycolic acid)-based scaffold for mastoid air-cell regeneration (2013)
Journal Article
Gould, T. W., Birchall, J. P., Mallick, A. S., Alliston, T., Lustig, L. R., Shakesheff, K. M., & Rahman, C. V. (2013). Development of a porous poly(DL-lactic acid-co-glycolic acid)-based scaffold for mastoid air-cell regeneration. Laryngoscope, 123(12), https://doi.org/10.1002/lary.24173

Objectives/Hypothesis: To develop a porous, biodegradable scaffold for mastoid air-cell regeneration. Study Design: In vitro development of a temperature-sensitive poly(DL-lactic acid-co-glycolic acid)/poly(ethylene glycol) (PLGA/PEG) scaffold tailo... Read More about Development of a porous poly(DL-lactic acid-co-glycolic acid)-based scaffold for mastoid air-cell regeneration.

Uptake and transport of B12-conjugated nanoparticles in airway epithelium (2013)
Journal Article
Fowler, R., Vllasaliu, D., Falcone, F. H., Garnett, M., Smith, B., Horsley, H., …Stolnik, S. (2013). Uptake and transport of B12-conjugated nanoparticles in airway epithelium. Journal of Controlled Release, 172(1), https://doi.org/10.1016/j.jconrel.2013.08.028

Non-invasive delivery of biotherapeutics, as an attractive alternative to injections, could potentially be achieved through the mucosal surfaces, utilizing nanoscale therapeutic carriers. However, nanoparticles do not readily cross the mucosal barrie... Read More about Uptake and transport of B12-conjugated nanoparticles in airway epithelium.

Desktop 3D printing of controlled release pharmaceutical bilayer tablets (2013)
Journal Article
Khaled, S. A., Burley, J. C., Alexander, M. R., & Roberts, C. J. (2014). Desktop 3D printing of controlled release pharmaceutical bilayer tablets. International Journal of Pharmaceutics, 461(1-2), 105-111. https://doi.org/10.1016/j.ijpharm.2013.11.021

Three dimensional (3D) printing was used as a novel medicine formulation technique for production of viable tablets capable of satisfying regulatory tests and matching the release of standard commercial tablets. Hydroxypropyl methylcellulose (HPMC 22... Read More about Desktop 3D printing of controlled release pharmaceutical bilayer tablets.

Self-reporting Scaffolds for 3-Dimensional Cell Culture (2013)
Journal Article
Harrington, H., Rose, F. R., Aylott, J. W., & Ghaemmaghami, A. M. (2013). Self-reporting Scaffolds for 3-Dimensional Cell Culture. Journal of Visualized Experiments, https://doi.org/10.3791/50608

Culturing cells in 3D on appropriate scaffolds is thought to better mimic the in vivo microenvironment and increase cell-cell interactions. The resulting 3D cellular construct can often be more relevant to studying the molecular events and cell-cell... Read More about Self-reporting Scaffolds for 3-Dimensional Cell Culture.