Outputs (10)

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., …Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

Potential Facilitators to the Implementation of the New Medicine Service in England (2012)
Journal Article
Wells, K., Boyd, M., Thornley, T., & Boardman, H. (2012). Potential Facilitators to the Implementation of the New Medicine Service in England. Research in Social and Administrative Pharmacy, 8(6), e45-e46. https://doi.org/10.1016/j.sapharm.2012.08.105

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces (2012)
Journal Article
Epa, V., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., …Winkler, D. A. (2012). Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. Journal of Materials Chemistry, 39(22), https://doi.org/10.1039/C2JM34782B

Designing materials to control biology is an intense focus of biomaterials and regenerative medicine research. Discovering and designing materials with appropriate biological compatibility or active control of cells and tissues is being increasingly... Read More about Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces.

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), 868-875. https://doi.org/10.1038/nbt.2316

Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput... Read More about Combinatorial discovery of polymers resistant to bacterial attachment.

Tissue transglutaminase (TG-2) modified amniotic membrane: A novel scaffold for biomedical applications (2012)
Journal Article
Chau, D. Y., Brown, S. V., Mather, M. L., Hutter, V., Tint, N. L., Dua, H. S., …Ghaemmaghami, A. M. (2012). Tissue transglutaminase (TG-2) modified amniotic membrane: A novel scaffold for biomedical applications. Biomedical Materials, 7(4), Article 045011. https://doi.org/10.1088/1748-6041/7/4/045011

The amniotic membrane (AM) is considered as a natural cell culture substrate and has occasionally been exploited in regenerative medicine especially for ocular surface reconstruction and dermal wound healing applications. However, its use is limited... Read More about Tissue transglutaminase (TG-2) modified amniotic membrane: A novel scaffold for biomedical applications.

Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction (2012)
Journal Article
Reddy, T. R., Li, C., Fischer, P. M., & Dekker, L. V. (2012). Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction. ChemMedChem, 7(8), https://doi.org/10.1002/cmdc.201200107

Protein interactions are increasingly appreciated as targets in small-molecule drug discovery. The interaction between the adapter protein S100A10 and its binding partner annexin A2 is a potentially important drug target. To obtain small-molecule sta... Read More about Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction.

Strategies for MCR image analysis of large hyperspectral data-sets (2012)
Journal Article
Scurr, D. J., Hook, A. L., Burley, J., Williams, P. M., Anderson, D. G., Langer, R., …Alexander, M. R. (2012). Strategies for MCR image analysis of large hyperspectral data-sets. Surface and Interface Analysis, 45(1), https://doi.org/10.1002/sia.5040

Polymer microarrays are a key enabling technology for high throughput materials discovery. In this study, multivariate image analysis, specifically multivariate curve resolution (MCR), is applied to the hyperspectral time of flight secondary ion mass... Read More about Strategies for MCR image analysis of large hyperspectral data-sets.

Sustained translational repression by eIF2?-P mediates prion neurodegeneration (2012)
Journal Article
Moreno, J. A., Radford, H., Peretti, D., Steinert, J. R., Verity, N., Martin, M. G., …Mallucci, G. R. (2012). Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature, 485(7399), 507-511. https://doi.org/10.1038/nature11058

The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer's, Parkinson's and prion diseases, are associated with the accumulation of misfolded disease-specific proteins.... Read More about Sustained translational repression by eIF2?-P mediates prion neurodegeneration.

In vitro and in vivo analysis of a novel highly selective ?1-adrenoceptor partial agonist. (2012)
Conference Proceeding
Baker, J. G., Mistry, S. N., Fischer, P. M., Hill, S. J., Gardiner, S. M., & Kellam, B. (2012). In vitro and in vivo analysis of a novel highly selective ?1-adrenoceptor partial agonist.

Professional skills development in a resource-poor setting: the case of pharmacy in Malawi (2012)
Journal Article
Lim, Z., Anderson, C., & McGrath, S. (2012). Professional skills development in a resource-poor setting: the case of pharmacy in Malawi. International Journal of Educational Development, 32(5), https://doi.org/10.1016/j.ijedudev.2012.01.004

The dominance of the human capital approach in vocational skills development has been increasingly questioned for being de-humanised and de-contextualised. Contrary to this trend, the discourse in health professional skills development has shown incr... Read More about Professional skills development in a resource-poor setting: the case of pharmacy in Malawi.