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Outputs (58)

Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease (2024)
Journal Article
Li, X., Sun, Y., Zhou, Z., Li, J., Liu, S., Chen, L., …Lu, Q. (2024). Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease. Advanced Science, https://doi.org/10.1002/advs.202308970

Alzheimer's disease (AD) is a pressing concern in neurodegenerative research. To address the challenges in AD drug development, especially those targeting Aβ, this study uses deep learning and a pharmacological approach to elucidate the potential of... Read More about Deep Learning‐Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease.

Targeted intradermal delivery of alpha-arbutin-loaded dissolving polymeric microneedles visualized by three-dimensional Orbitrap secondary ion mass spectrometry (3D OrbiSIMS) (2024)
Journal Article
Li, Z., Marlow, M., Scurr, D., & Zhu, Z. (2024). Targeted intradermal delivery of alpha-arbutin-loaded dissolving polymeric microneedles visualized by three-dimensional Orbitrap secondary ion mass spectrometry (3D OrbiSIMS). European Journal of Pharmaceutics and Biopharmaceutics, 196, Article 114181. https://doi.org/10.1016/j.ejpb.2024.114181

Hyperpigmentation, a prevalent dermatological condition characterized by melanin overproduction, poses treatment challenges due to the hydrophilicity of alpha-arbutin, a widely utilized tyrosinase inhibitor. This study investigates... Read More about Targeted intradermal delivery of alpha-arbutin-loaded dissolving polymeric microneedles visualized by three-dimensional Orbitrap secondary ion mass spectrometry (3D OrbiSIMS).

Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors (2023)
Journal Article
Hu, Z., Zhou, S., Li, J., Li, X., Zhou, Y., Zhu, Z., …Liu, J. (2023). Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors. Future Medicinal Chemistry, 15(20), 1823-1841. https://doi.org/10.4155/fmc-2023-0206

Aim: Based on a multitarget design strategy, a series of novel indanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Results: These compounds exhibited significant inhibitory acti... Read More about Design, synthesis and biological evaluation of novel indanones derivatives as potent acetylcholinesterase/monoamine oxidase B inhibitors.

Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis (2023)
Journal Article
Zhu, W., Wu, H., He, C., Zhu, H., Yao, H., Cao, Y., …Xu, J. (2023). Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis. RSC Medicinal Chemistry, https://doi.org/10.1039/d3md00447c

Herein, a series of novel β-elemene hybrids with different types of hydrogen sulfide (H2S) donors was designed and synthesized for the first time. In addition, all compounds were tested for H2S release in phosphate buffer solution assay, among which... Read More about Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis.

Hydrocortisone Mitigates Alzheimer’s-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation (2023)
Journal Article
Li, J., Chen, L., Liu, S., Sun, Y., Zhen, L., Zhu, Z., …Li, X. (2023). Hydrocortisone Mitigates Alzheimer’s-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation. Cells, 12(19), Article 2348. https://doi.org/10.3390/cells12192348

Alzheimer’s disease (AD), an age-related degenerative disorder, is characterized by β-amyloid deposition, abnormal phosphorylation of tau proteins, synaptic dysfunction, neuroinflammation, and oxidative stress. Despite extensive research, there are n... Read More about Hydrocortisone Mitigates Alzheimer’s-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation.

Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers (2023)
Journal Article
Vrettos, N., Wang, P., Wang, Y., Roberts, C. J., Xu, J., Yao, H., & Zhu, Z. (2023). Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers. Pharmaceutical Development and Technology, 28(8), 724-742. https://doi.org/10.1080/10837450.2023.2238822

In the present study, novel gastroretentive bilayer tablets were developed that are promising for the once-a-day oral delivery of the drug candidate MT-1207. The gastroretentive layer consisted of a combination of hydrophilic and hydrophobic polymers... Read More about Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers.

Asiaticoside Mitigates Alzheimer’s Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function (2023)
Journal Article
Liu, S., Chen, L., Li, J., Sun, Y., Xu, Y., Li, Z., …Li, X. (2023). Asiaticoside Mitigates Alzheimer’s Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function. International Journal of Molecular Sciences, 24(15), Article 11976. https://doi.org/10.3390/ijms241511976

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, hallmarked by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Due to the uncertainty of the pathogenesis of AD, strategies aimed at suppressing neuroinflammat... Read More about Asiaticoside Mitigates Alzheimer’s Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function.

Dual roles of demethylation in cancer treatment and cardio-function recovery (2023)
Journal Article
Li, X., Shen, D., Zhu, Z., Lyu, D., He, C., Sun, Y., …Wang, G. (2023). Dual roles of demethylation in cancer treatment and cardio-function recovery. Redox Biology, 64, Article 102785. https://doi.org/10.1016/j.redox.2023.102785

There are no effective therapeutic targets or strategies that simultaneously inhibit tumour growth and promote cardiac function recovery. Here, we analyzed targets for cancer treatments and cardiac repair, with demethylation emerging as a common fact... Read More about Dual roles of demethylation in cancer treatment and cardio-function recovery.

Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo (2023)
Journal Article
Zhu, H., Zhu, W., Liu, Y., Gao, T., Zhu, J., Tan, Y., …Xu, S. (2023). Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo. European Journal of Medicinal Chemistry, 257, Article 115529. https://doi.org/10.1016/j.ejmech.2023.115529

A series of novel stilbene-based derivatives were designed and synthesized as tubulin/HDAC dual-target inhibitors. Among forty-three target compounds, compound II-19k not only exhibited considerable antiproliferative activity in the hematological cel... Read More about Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo.

Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease (2023)
Journal Article
Sun, Y., Li, J., A, N., Li, Z., Zhong, W., Chen, L., …Li, X. (2023). Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease. Frontiers in Immunology, 14, Article 1192940. https://doi.org/10.3389/fimmu.2023.1192940

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and linked to abnormal deposition of amyloid-β (Aβ), neurofibrillary tangles (NFTs), synaptic dysfunction, and neuroinflammation. Despite significant progress in unravelling the path... Read More about Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease.